A case of intrahepatic clear cell cholangiocarcinoma

Table 1 Reported cases of intrahepatic cholangiocarcinoma clear cell variant

Yr	Age (yr)/sex	Location	Size (cm)	Hepatitis	Liver cirrhosis	Mechanism	Prognosis
1998[10]	64/F	Unknown	12	Unknown	Unknown	Unknown	Unknown
1998[11]	62/M	Right lobe	5	-	-	Unknown	Dead, 14 mo; no treatment
1998[7]	72/M	Left lobe	15	Unknown	Unknown	Lipid >> glycogen	Alive, 30 mo
1999[8]	50/M	S6	1.5	-	Unknown	Mucin	Alive, 12 mo
2001[9]	64/M	Right lobe	6	-	-	Unknown	Alive, 3 yr
2007[4]	51/M	S4a	9	Unknown	-	Lipid >> glycogen	Meta, 1 yr; dead, 3 yr
2007[4]	60/F	S5	4.5	Unknown	-	Lipid >> glycogen	Alive, 1 yr
2007[4]	58/F	S5	2.3	Unknown	-	Lipid >> glycogen	Alive
Present case	56/M	S7	2.2	HBV	-	Glycogen	Alive, 7 mo

M: Male; F: Female; S: Segment; meta: Metastasis.

Table 2 Serum data on admission

Item	Data	Normal values
HBs-Ag (C.O.I)	277.5	< 1.0
HBs-Ab (mIU/mL)	165.1	< 5.0
Anti-HCV-Ab (C.O.I)	0.1	< 1.0
α-fetoprotein (ng/mL)	3.6	≤ 7.0
PIVKA-II (mAU/mL)	17.0	< 40.0
Carcinoembryonic antigen (ng/mL)	2.4	≤ 5.0
Total cholesterol (mg/dL)	181.0	128-25
Aspartate aminotransferase ( IU/L)	28.0	13-33
Alanine aminotransferase (IU/L)	21.0	8-42
Alkaline phosphatase (IU/L)	198.0	115-359
Lactate dehydrogenase (IU/L)	207.0	119-229
γ-glutamyl transpeptidase (IU/L)	30.0	10-47

HBs-Ag: Hepatitis B surface antigen; HBs-Ab: Hepatitis B surface antibody; anti HCV-Ab: Anti hepatitis C virus antibody; PIVKA: Protein induced by vitamin K absence; C.O.I: Cut off index.

Table 3 Immunohistochemical staining

Antibody	Company	Result
CK7	DAKO	+
CK19	DAKO	+
CK20	DAKO	-
CAM5.2	Becton, Dickinson, and Co.	+
EMA	DAKO	+
CA19-9	DAKO	+ focal
CEA	DAKO	-
CD56	DAKO	+ focal
AE1/3	DAKO	+
Ki-67 (MIB-1)	Novocastra	7.5%1
p53	Novocastra	+ focal
Bcl-2	DAKO	-
TTF-1	DAKO	-
Hepatocyte	DAKO	-
a-Fetoprotein	DAKO	-
Vimentin	DAKO	-
CD10	DAKO	-
S-100 protein	DAKO	-
Chromogranin	DAKO	-
Synaptophysin	DAKO	-

¹Ki-67(MIB-1) index was estimated at the most frequent area. CAM: Cell adhesion molecule; CEA: Carcinoembryonic antigen; TTF-1: Thyroid transcription factor-1; CD: Cluster of differentiation.