Clinical outcomes in patients with ICU-related pancreatitis

Table 1 Comparison of the differences between ICU survivors and ICU non-survivors in patients with ventilator-related pancreatitis (mean ± SD) n (%)

Characteristics	ICU survivorsn = 35 (58.3)	ICU non-survivorsn = 25 (41.7)	P
Age	60.77 ± 20.71	66.72 ± 15.73	0.232
Male gender	19 (54.3)	17 (80)	0.004
Apache II score	24.69 ± 6.09	29.88 ± 5.15	0.001
Lowest PaO2/FiO2	283.86 ± 64.13	175.32 ± 72.72	< 0.001
Lipase level	830.93 ± 511.05	1374.88 ± 1391.60	0.072
Amylase level	227.34 ± 207.35	374.96 ± 368.87	0.079
ARDS	5 (14.3)	13 (52)	0.002
SIRS	5 (17.2)	13 (52)	0.002
Vasopressor	12 (34.3)	9 (36)	0.891
Acute renal failure	11 (31.4)	17 (68)	0.005
RRT	2 (5.7)	9 (36)	0.003
CHF	26 (74.3)	11 (44)	0.017
CVA	12 (34.3)	10 (40)	0.651
Liver cirrhosis	8 (22.9)	7 (28)	0.650
COPD	12 (34.3)	8 (32)	0.853
Neoplastic disease	3 (8.6)	5 (20)	0.199
Diabetes mellitus	17 (48.6)	12 (48)	0.965
Hypertension	19 (54.3)	15 (60)	0.660

Variables are expressed as mean (standard deviation) and categorical data are expressed as number (percentage). Continuous variables were analyzed by Student’s t test or Mann-Whitney U test, and categorical data by χ² test. ICU: Intensive care unit; Apache: Acute Physiology and Chronic Health Evaluation; ARDS: Acute respiratory distress syndrome; SIRS: Systemic inflammatory response syndrome; RRT: Renal replacement therapy; CHF: Congestive heart failure; CVA: Cerebrovascular disease; COPD: Chronic obstructive pulmonary disease.

Table 2 Comparison of baseline characteristics, clinical features, comorbidities and ICU mortality in groups (mean ± SD) n (%)

	Ventilator-related pancreatitis (n = 60)	Controls (n = 180)	Pancreatitis related respiratory failure (n = 88)
Age	63.3 ± 18.9	65 ± 15	59.3 ± 18.7
Male gender	39 (65)	110 (61.1)	54 (61.4)
Serum lipase level	1057.3 ± 1005.7	-	8274.4 ± 17018.6a
Serum amylase level	288.9 ± 292.4	-	884.6 ± 1247.0a
Apache II score	26.9 ± 6.2	26 ± 6	32.0 ± 6.8a
Lowest PaO2/FiO2	238.6 ± 86.2	224.9 ± 60.2	168.8 ± 66.5a
ARDS	18 (30)	62 (34.4)	60 (68.1)a
SIRS	18 (30)	66 (36.7)	47 (53.4)a
Vasopressor	21 (35)	64 (35.6)	49 (55.7)a
RRT	11 (18.3)	31 (17.2)	24 (27.2)
Coexisting illness
Congestive heart failure	37 (61.7)	105 (58.3)	32 (36.4)a
Cerebrovascular disease	22 (36.7)	67 (37.8)	22 (25)
Acute renal failure	28 (46.7)	68 (37.8)	36 (40.9)
Liver cirrhosis	15 (25)	48 (26.7)	41 (46.6)a
Obstructive lung disease	20 (33.3)	71 (39.4)	20 (22.7)
Neoplastic disease	8 (13.3)	28 (15.6)	18 (20.5)
Diabetes mellitus	29 (48.3)	97 (53.9)	39 (44.3)
Hypertension	34 (56.7)	106 (58.9)	31 (35.2)
ICU mortality	25 (41.7)	67 (37.2)	65 (73.8)a

Continuous variables were analyzed by Student’s t test or Mann-Whitney U test, and categorical data by χ² test.

^aP < 0.01 compared with ventilator-related pancreatitis.

Table 3 Predictors of ICU mortality in patients with ventilator-related pancreatitis by univariate and multivariate logistic regression analysis

Predictors	Odd Ratio (95% CI)	P
Univariate analysis
Apache II score	0.856 (0.772-0.948)	0.003
Lowest PaO2/FiO2	1.021 (1.011-1.032)	< 0.001
ARDS	6.500 (1.901-22.229)	0.003
SIRS	6.500 (1.901-22.229)	0.003
Acute renal failure	4.636 (1.540-13.963)	0.006
RRT	9.281 (1.792-48.057)	0.008
Male gender	3.368 (1.031-11.010)	0.044
Amylase level	0.998 (0.996-1.000)	0.080
Lipase level	0.999 (0.999-1.000)	0.070
Multivariate analysis
Lowest PaO2/FiO2	1.032 (1.006-1.059)	0.016

CI: Confidence interval.