Surgical outcome of carcinosarcoma of the gall bladder: A review

Table 1 Thirty six reported cases of surgical resection for carcinosarcoma of the gall bladder

Author	Year	Age (yr)	Sex	Palpation	Position	Stone	Size (cm)	Depth	SCC	Stage	Survival (mo)
Mehrotra et al[2]	1971	45	F	+	Neck	+	10	si	+	III	4
Higgs et al[3]	1973	77	M	-	Neck	-	ND	bd	+	IVa	1
Mansori et al[4]	1980	81	M	+	Body	-	15	liver	ND	IVa	1.5
Aldovini et al[5]	1982	75	F	+	Body	+	9	mp	-	III	81
Von Kuster et al[6]	1982	77	F	-	Fundus	-	3	mp	ND	II	311
Born et al[7]	1984	90	F	+	Body	+	15	du	ND	IVa	3
Inoshita et al[8]	1986	53	M	+	Neck	-	11	bd	+	IVa	17
Suster et al[9]	1987	54	F	+	Body	+	8	si	+	III	ND
Lumsden et al[10]	1988	81	F	+	Neck	-	5	mp	ND	II	121
Guo et al[11]	1988	69	M	ND	ND	ND	ND	ND	-	ND	3
		61	M	ND	ND	ND	ND	ND	-	ND	3
		66	M	ND	ND	ND	ND	ND	+	ND	191
Ishihara et al[12]	1990	58	F	-	Fundus	-	8	mp	-	II	71
Nishihara et al[13]	1993	63	F	ND	ND	-	9.5	ND	-	ND	391
		66	F	ND	ND	+	5	ND	-	ND	1
		70	F	ND	ND	-	4.2	ND	-	ND	7
		75	F	ND	ND	-	16	ND	+	ND	6
		80	F	ND	ND	-	5	ND	-	ND	1.5
Fagot et al[14]	1994	83	F	-	Fundus	+	4.5	mp	ND	II	121
Nakagawa et al[15]	1996	66	F	-	Fundus	-	7	liver	ND	IVa	ND
Rys et al[16]	1998	67	F	+	Fundus	-	15	liver, cln	ND	IVa	2
Eriguchi et al[17]	1999	65	F	+	ND	+	10	mp	ND	II	161
Ajiki et al[18]	2002	69	F	-	Body	+	6	liver	-	IVa	7
Hotta et al[19]	2002	53	M	+	Body	+	11	mp	-	II	7
Kim et al[20]	2003	61	F	+	Neck	-	4.5	si	-	IVa	21
Takahashi et al[21]	2004	84	F	-	Body	-	8	si	+	IVa	2
Huguet et al[22]	2005	64	F	-	Body	-	12	panc	+	IVa	4
Sodergren et al[23]	2005	68	F	-	Neck	-	9	bd	-	IVa	5
Kubota et al[24]	2006	72	M	+	Body	-	7	liver, col	-	IVa	8
Liu et al[25]	2009	51	M	ND	ND	ND	ND	si	-	IVa	3
		65	F	ND	ND	ND	ND	si	-	IVa	0.7
		56	F	ND	ND	ND	ND	si	-	IVa	5
Agarwal et al[26]	2009	60	F	+	Body	-	7	mp	-	II	31
Uzun et al[27]	2009	70	M	+	Fundus	-	10	mp	-	II	541
Shimada et al[28]	2009	69	M	-	Body	+	9	si	-	II	61
Present case	2009	72	F	-	Body	-	2.5	mp	-	II	601

¹Alive patients. SCC: Squamous cell carcinoma component; si: Serosal invasion; bd: Bile duct; mp: Muscularis propria; cln: Colon; panc: Pancreas; ND: Not described; Stage: Classification according to UICC (International Union Against Cancer).

Table 2 Clinical characteristics after surgical resection for carcinosarcoma of the gall bladder

Characteristics	n	Survival rate (%)			Median survival in months (range)	P value
		1 yr	2 yr	3 yr
Overall	36	37.2	31.0	31.0	7.0 (4.4-9.6)
Age (yr)
< 65	14	37.7	18.9	18.9	5.0 (0.3-9.7)	0.887
> 65	22	36.7	36.7	36.7	7.0 (4.2-9.8)
Gender
Male	10	36.0	24.0	24.0	6.0 (0.3-13.7)	0.877
Female	26	37.5	37.5	37.5	6.0 (3.3-8.7)
Palpable mass
Present	14	48.0	48.0	48.0	7.0	0.853
Absent	11	47.6	23.8	23.8	8.0 (0.0-16.9)
Stone
Present	10	40.0	-	-	7.0 (3.2-10.8)	0.937
Absent	20	42.1	33.7	33.7	7.0 (3.4-10.6)
Size of the tumor (cm)
< 5	8	60.0	60.0	60.0	-	0.361
> 5	21	36.6	24.4	24.4	7.0 (5.1-8.9)
Si or organ invasion
Present	18	9.2	0.0	0.0	4.0 (2.2-5.8)	0.001
Absent	10	88.9	88.9	88.9	-
Scc component
Present	8	28.6	14.3	-	4.0 (1.4-6.6)	0.291
Absent	16	31.2	31.2	31.2	7.0 (4.8-9.2)
Stage
II	10	87.5	87.5	87.5	-	0.001
III or IVa	18	13.8	0.0	0.0	4.0 (2.2-5.8)
Changing trends
1970-1989	12	45.5	30.3	-	4.0 (0.0-12.9)	0.920
1990-1999	10	44.4	44.4	-	7.0 (4.1-9.9)
2000-2009	14	20.8	20.8	20.8	7.0 (4.8-9.2)

Scc: Squamous cell carcinoma; Si: Serosal invasion; Stage: Classification according to International Union Against Cancer (UICC).