A systematic review of treating Helicobacter pylori infection with Traditional Chinese Medicine

Table 1 Characteristics of randomized and controlled clinical trials treating Helicobacter pylori infection with TCM

Trials	No. of cases	Age (yr)	Gender (male) (%)	Jadad score	Regimen of TCM group	Regimen of triple therapies group
Chen et al[10] (2001)	419	23-68	62.1	2	Fixed formula × 7 d	(PPI + A + F) × 7 d
Hua et al[11] (2003)	155	19-65	54.2	2	Changweiqing oral liquid × 14 d	(CBS + A + F) × 14 d
Fan et al[12] (2006)	50	NA	NA	1	Anzhong Yin× 28 d	(CBS + A + F) × 14 d
Hua et al[13] (2006)	150	23-85	61.3	1	Jianwei Mieyou Inspissant × 60 d	(CBS + A + C) × 7 d + CBS × 49 d
Ma et al[14] (2006)	106	44.2/43.8	79.3	2	Weikang Capsule × 60 d	(RBC + A + M) × 14 d
Wang et al[15] (2006)	77	NA	47.7	1	Jianpi Qinghua formula × 30 d	(CBS + A + T) × 14 d
Wu[16] (2006)	71	19-65	67.6	2	Jiawei Liumo Decoction × 56 d	(PPI + A + M) × 10 d
Yang et al[17] (2006)	80	22-65	70	2	Weitongning Tab × 28 d	(CBS + A + M) × 14 d
Zhou et al[18] (2006)	56	23-70	47.2	2	Qingwei Decoction × 14 d	(PPI + A + M) × 14 d
Huang[19] (2007)	320	18-77	55.6	2	Maimendong Granule × 28 d	(PPI + A + M) × 14 d
Jin et al[20] (2007)	98	18-72	67.4	2	Maimendong Granule × 28 d	(PPI + A + M) × 7 d
Wang et al[21] (2008)	60	20-64	61.7	1	Mieyou Decoction × 14 d	(CBS + A + T) × 14 d
Ling et al[22] (2008)	46	33.2/35.1	71.7	2	Jianwei Yuyang Granule × 6 wk	(PPI + A + M) × 1 wk + PPI × 1 wk
Wang[23] (2008)	149	16-66	61.7	2	Formulae × 2 w	(CBS + A + M) × 2 wk
Xiao et al[24] (2008)	80	19-77	62.5	2	Weiyan Decoction × 20 d	(PPI + A + C) × 7 d
Xin et al[25] (2008)	70	48.6/44.6	60	2	Weikang formula × 1 mo	(PPI + C + T) × 7 d

TCM: Traditional Chinese Medicine; PPI: Proton pump inhibitor; CBS: Colloidal bismuth subcitrate; RBC: Ranitidine bismuth citrate; A: Amoxillin; M: Metronidazole; T: Tinidazole; C: Clarithromycin; F: Furazolidone. NA: No available.

Table 2 H pylori eradication rates comparison between TCM and triple therapies

Trials	TCM (n/N)	Triple therapies (n/N)	RR (95% CI)	P	Ref.
Fixed formula vs PPI + A + F	161/211	160/204	1.02 (0.91, 1.13)	0.60	[10]
Anzhong Yin vs CBS + A + F	19/30	14/20	0.90 (0.61, 1.34)	0.63	[12]
Jianwei Mieyou Inspissant vs CBS + A + C	60/100	22/50	1.43 (1.01, 2.03)	0.06	[13]
Weikang Capsule vs RBC + A + M	46/56	42/50	0.98 (0.82, 1.16)	0.80	[14]
Jiawei Liumo Decoction vs PPI + A + M	37/41	28/30	0.97 (0.84, 1.11)	0.64	[16]
Weitongning Tab vs CBS + A + M	32/40	31/40	1.03 (0.82, 1.30)	0.78	[17]
Qingwei Decoction vs PPI + A + M	13/29	19/27	0.64 (0.40, 1.02)	0.05	[18]
Maimendong Granule vs PPI + A + M	166/200	98/120	1.02 (0.91, 1.13)	0.76	[19]
Maimendong Granule vs PPI + A + M	43/50	40/48	1.03 (0.87, 1.22)	0.71	[20]
Mieyou Decoction vs CBS + A + T	22/32	19/28	1.01 (0.73, 1.43)	0.88	[21]
Formulae vs CBS + A + M	81/93	49/56	1.00 (0.88, 1.13)	0.94	[23]
Weiyan Decoction vs PPI + A + C	28/40	29/40	0.97 (0.73, 1.28)	0.80	[24]
Changweiqing oral liquie vs CBS + A + F	53/103	36/52	0.74 (0.57, 0.96)	0.03	[11]
Jianpi Qinghua formula vs CBS + A + T	15/42	29/35	0.43 (0.28, 0.66)	< 0.01	[15]
Jianwei Yuyang Granule vs PPI + A + M	11/24	18/22	0.56 (0.35, 0.90)	0.01	[22]
Weikang formula vs PPI + C + T	26/40	26/30	0.75 (0.57, 0.98)	0.04	[25]

RR: Relative risk; CI: Confidence interval.