Shirabe K, Kajiyama K, Harimoto N, Masumoto H, Fukuya T, Ooya M, Maehara Y. Prognosis of hepatocellular carcinoma accompanied by microscopic portal vein invasion. World J Gastroenterol 2009; 15(21): 2632-2637 [PMID: 19496194 DOI: 10.3748/wjg.15.2632]
Corresponding Author of This Article
Ken Shirabe, MD, PhD, FACS, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. kshirabe@surg2.med.kyushu-u.ac.jp
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World J Gastroenterol. Jun 7, 2009; 15(21): 2632-2637 Published online Jun 7, 2009. doi: 10.3748/wjg.15.2632
Table 1 Univariate analysis of clinicopathological prognostic factors for cumulative survival rate
Factors
Survival rate (%)
P value
1 yr
3 yr
5 yr
Age (yr)
< 67 (n = 27)
80.6
60.4
42.1
0.9546
≥ 67 (n = 28)
96.6
75.7
50.0
Gender
Male (n = 41)
92.6
72.3
45.2
0.7614
Female (n = 14)
78.6
50.0
42.9
Platelets (104/mm3)
< 1.5 (n = 27)
92.6
61.7
46.6
0.7341
≥ 1.5 (n = 28)
85.7
67.5
46.0
Albumin (g/dL)
< 3.9 (n = 27)
100
76.9
47.2
0.6123
≥ 3.9 (n = 28)
79.0
56.8
47.5
Tumor size (cm)
< 4.3 (n = 27)
92.4
72.8
35.9
0.8752
≥ 4.3 (n = 28)
85.7
60.7
52.0
AFP (ng/mL)
0-27 (n = 28)
96.4
71.3
55.4
0.1001
> 27 (n = 27)
81.2
61.6
35.8
DCP (mAU/mL)
0-300 (n = 18)
94.1
75.1
75.1
0.1834
≥ 300 (n = 18)
83.3
55.6
55.6
Operative procedure
Anatomical resection (n = 32)
90.5
74.2
51.4
0.0620
Non-anatomic resection (n = 23)
87.0
55.9
39.5
Tumor grade of differentiation
Moderate (n = 38)
97.3
70.0
54.9
0.1076
Poor (n = 17)
70.6
58.8
30.3
IM (-) (n = 31)
96.8
66.7
56.5
0.2625
IM (+) (n = 24)
79.2
66.7
32.8
PVI-S (n = 44)
97.7
76.5
51.2
0.0019
PVI-M (n = 11)
54.5
27.3
27.3
Table 2 Univariate analysis of clinicopathological prognostic factors for disease-free survival rate
Factors
Survival rates (%)
P value
1 yr
3 yr
5 yr
Age (yr)
< 67 (n = 27)
54.7
31.9
31.9
0.7438
≥ 67 (n = 28)
72.5
21.3
Gender
Male (n = 41)
68.7
27.3
22.7
0.2716
Female (n = 14)
48.6
19.4
19.4
Platelets (104/mm3)
< 1.5 (n = 27)
52.8
7.9
7.9
0.1703
≥ 1.5 (n = 28)
74.2
33.7
33.7
Albumin (g/dL)
< 3.9 (n = 27)
61.5
22.6
16.9
0.8555
≥ 3.9 (n = 28)
65.8
29.4
29.4
Tumor size (cm)
< 4.3 (n = 27)
62.9
35.0
35.0
0.4474
≥ 4.3 (n = 28)
64.8
17.0
11.3
AFP (ng/mL)
0-27 (n = 28)
59.1
39.4
39.4
0.1692
> 27 (n = 27)
68.0
14.6
9.7
DCP (mAU/mL)
< 300 (n = 18)
72.5
43.5
43.5
0.2995
≥ 300 (n = 18)
63.0
21.0
14.0
Operative procedure
Anatomical resection (n = 32)
82.3
33.0
33.0
0.0074
Non-anatomical resection (n = 23)
40.9
17.0
11.4
Tumor grade of differentiation
Moderate (n = 38)
69.3
36.7
31.4
0.0661
Poor (n = 17)
52.9
7.4
7.4
IM (-) (n = 31)
67.1
28.2
23.5
0.4761
IM (+) (n = 24)
59.8
22.1
22.1
PVI-S (n = 44)
74.6
27.4
23.5
0.0072
PVI-M (n = 11)
20.0
20.0
Table 3 Comparison of recurrence patterns for 55 HCC patients with single or multiple PVI n (%)
Recurrence pattern
None
Nodular
Multiple
PVI-S (n = 44)
16 (36)
15 (34)
13 (30)
PVI-M (n = 11)
2 (18)
0
9 (82)
Table 4 Impact of operative procedures (non-anatomical versus anatomical resection) was examined in patients with PVI-S, depending on cumulative survival rate and disease-free survival rates
Factors
Survival rates (%)
P value
1 yr
3 yr
5 yr
Cumulative survival
Anatomical resection (n = 26)
96.2
83.9
55.0
0.0782
Non-anatomical resection (n = 18)
100
65.8
46.1
Disease-free survival
Anatomical resection (n = 26)
90.9
32.2
32.2
0.0370
Non-anatomical resection (n = 18)
52.9
22.1
14.7
Table 5 Impact of operative procedures (non-anatomical versus anatomical resection) was examined in patients with PVI-M, depending on cumulative survival and disease-free survival rates
Factors
Survival rates (%)
P value
1 yr
3 yr
5 yr
Cumulative survival
Anatomical resection (n = 6)
66.7
33.3
33.3
0.4497
Non-anatomical resection (n = 5)
40.0
20.0
20.0
Disease-free survival
Anatomical resection (n = 6)
40.0
20.0
20.0
0.2651
Non-anatomical resection (n = 5)
0
Citation: Shirabe K, Kajiyama K, Harimoto N, Masumoto H, Fukuya T, Ooya M, Maehara Y. Prognosis of hepatocellular carcinoma accompanied by microscopic portal vein invasion. World J Gastroenterol 2009; 15(21): 2632-2637