Rocket “Eruca sativa”: A salad herb with potential gastric anti-ulcer activity

Table 1 Effects of EER on gastric secretion, acidity and gastric lesion index in pylorus-ligated shay rats (mean ± SE)

Group serial	Treatment	Dose (mg/kg, i.g.)	Volume of gastric content (mL)	Titratable acidity (mEq/L)	Ulcer index
1	Control (distilled water)	-	10.83 ± 1.16	196.57 ± 15.50	2.33 ± 1.50
2	EER	250	6.33 ± 1.63a	132.77 ± 17.43a	0.66 ± 0.51a
3	EER	500	4.16 ± 1.16b	55.55 ± 10.46d	0.50 ± 0.54a

Six rats were used in each group.

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs control (distilled water) group, Student’s t-test.

Table 2 Effect of EER on gastric lesions induced by necrotizing agents (mean ± SE)

Group serial	Treatment	Dose (mg/kg, i.g.)	Ulcer index
			80% EtOH	0.2 mol/L NaOH	25% NaCl
1	Control (distilled water)	-	6.00 ± 0.89	6.66 ± 1.36	6.66 ± 0.51
2	EER	250	2.00 ± 0.89b	2.66 ± 1.21a	2.83 ± 0.98b
3	EER	500	1.66 ± 1.03b	1.50 ± 0.54b	2.16 ± 0.75d

Six rats were used in each group.

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs control (distilled water) group, Student’s t-test.

Table 3 Effect of EER on indomethacin-induced gastric mucosal lesions (mean ± SE)

Group serial	Treatment	Animals (n)	Dose (mg/kg, i.g.)	Ulcer Index
1	Control (indomethacin only)	6	-	44.50 ± 5.82
2	EER	6	250	25.50 ± 6.88
3	EER	6	500	13.50 ± 4.84b

Six rats were used in each group.

^bP < 0.01 vs control (indomethacin only) group, Student’s t-test.

Table 4 Effect of EER on hypothermic restraint stress-induced intraluminal bleeding and gastric lesions in rats (mean ± SE)

Group serial	Treatment	Dose (mg/kg, i.g.)	Intraluminal bleeding score	Gastric lesion ulcer index
1	Control (distilled water)	-	2.60 ± 0.50	24.00 ± 3.24
2	EER	250	1.20 ± 0.83	15.20 ± 3.96
3	EER	500	0.83 ± 0.40a	7.66 ± 6.12a

Six rats were used in each group.

^aP < 0.05 vs control (distilled water) group, Student’s t-test.