Liver Cancer
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Oct 7, 2008; 14(37): 5665-5673
Published online Oct 7, 2008. doi: 10.3748/wjg.14.5665
Table 1  Expression of five cell adhesion molecules in HCCs n (%)
E-cadherinα-cateninβ-cateninγ-cateninp120
Normal40 (41.2)32 (35.0)42 (35.0)37 (37.5)35 (42.5)
Reduced41 (42.3)46 (65.0)42 (65.0)50 (62.5)47 (57.5)
Absent16 (16.5)19131015
Table 2 Distribution of complex expression in HCCs
MembraneCytoplasmNucleus
E-cadherin97 00
α-catenin70270
β-catenin55366
γ-catenin63340
p12065320
Table 3 Relationship between expression of E-cadherin/catenin complex and histological features and clinical parameters in HCCs
E-cadherinα-cateninβ-cateninγ-cateninp120ctn
n+/-+/-+/-+/-+/-
Histological grade
 I-II2320/319/422/120/319/4
III5817/4111/4720/3811/4715/43
IV163/132/142/143/131/15
P0.0000.0000.0000.0000.000
Histological stage
 I-II4724/2322/2527/2025/2227/20
III3712/255/3210/2710/276/31
IV14 4/103/115/92/122/12
P0.1360.0030.0170.0070.000
Tumor size
< 3 cm2915/1417/1218/1117/1219/10
3-10 cm5018/3210/4016/3413/3712/38
> 10 cm187/115/138/107/114/14
P0.3820.0020.0340.0160.000
Capsular invasion
Present97/26/36/35/45/4
Absent8833/5526/6236/5232/5630/58
P0.0030.0550.1690.2950.277
Satellite nodules
Present2410/148/1612/127/178/16
Absent7330/4324/4030/4330/4327/46
P1.0001.0000.4830.3410.811
Vascular invasion
Present268/188/1812/1410/167/19
Absent7132/3924/4730/4127/4428/43
P0.2491.000 0.8181.0000.341
Lymph node permission
Present174/133/148/96/115/12
Absent8036/4429/5134/4631/4930/50
P0.1140.1160.7911.0000.59
Intrahepatic metastasis
Present327/255/279/237/256/26
Absent6533/3227/3833/3230/3529/36
P0.0080.0120.0490.0260.014
AFP-value
< 20 ng/dL286/1213/1516/1214/1415/13
> 20 ng/dL6924/4519/5026/4323/4620/49
P0.0680.0960.1130.1670.035
Table 4 Relationship between E-cadherin and catenin expressions in HCCs
α-catenin
β-catenin
γ-catenin
p120
+-+-+-+-
E-catenin+28123372911319
-453948849453
P0.0000.0000.0000.000