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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 21, 2008; 14(23): 3681-3692
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3681
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3681
Table 1 Inhibition of cell growth by NVP-LAQ824 and NVP-LBH589
| Cell line | IC50 (&mgr;mol/L) | |||
| NVP-LAQ824 | NVP-LAQ589 | |||
| 3 d | 6 d | 3 d | 6 d | |
| MiaPaca-2 | 0.03 | 0.01 | 0.01 | 0.01 |
| As-PC-1 | 0.05 | 0.02 | 0.02 | 0.01 |
| Panc-1 | 0.70 | 0.04 | 0.40 | 0.02 |
| Hs766T | 0.02 | 0.01 | 0.01 | 0.01 |
| CFPAC-1 | 0.25 | 0.04 | 0.09 | 0.02 |
| HPAF-2 | 0.16 | 0.12 | 0.07 | 0.06 |
| L3.6pl | 0.05 | 0.02 | 0.03 | 0.04 |
| Capan-2 | > 1 | 0.19 | > 1 | 0.05 |
Table 2 MIB-1- and TUNEL-staining of mouse tumor specimens
| Mean in % | HPAF-2 | L3.6pl | ||
| MIB-1 | Apoptosis | MIB-1 | Apoptosis | |
| CTRL | 67.5 | 1.3 | 61.3 | 0 |
| GEM | 66.3 | 2.5 | 70 | 0 |
| LBH | 51.3 | 3.8 | 76.3 | 6.3 |
| COMBO | 55.0 | 3.8 | 78.8 | 3.8 |
- Citation: Haefner M, Bluethner T, Niederhagen M, Moebius C, Wittekind C, Mossner J, Caca K, Wiedmann M. Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors. World J Gastroenterol 2008; 14(23): 3681-3692
- URL: https://www.wjgnet.com/1007-9327/full/v14/i23/3681.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.3681