DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese

Table 1 Distribution of selected variables in esophagus cancer patients and control subjects n (%)

Variables	Patients (n = 194 )	Control (n = 210 )	P
Age (yr)			> 0.05
< 40	1 (0.5)	2 (0.9)
40-60	117 (60.3)	110 (52.4)
61-80	76 (39.2)	98 (46.7)
Sex			> 0.05
Male	150 (77.3)	146 (69.5)
Female	44 (22.7)	64 (30.5)

Table 2 DNMT3B genotype and allele frequency in Chinese and Koreans

	TT	GT	GG	G allele frequency (%)
Chinese	169 (80.5)	40 (19.0)	1 (0.5)	10.0
Korean	153 (61.7)	91 (36.7)	4 (1.6)	20b

^bP < 0.01 vs Chinese.

Table 3 DNMT3B genotype and allele frequency in patients and control subjects and their association with esophagus cancer n (%)

	Case patients	Control subjects
	(n = 194 )	(n = 210 )	OR (95% CI)
DNMT3B 579 G>T
TT	151 (77.8)	169 (80.5)
GT	43 (22.2)	40 (19.0)	1.17 (0.73-1.90)
GG	0 (0)	1 (0.50)
G allele (%)	11.1	10.0

Table 4 Stratification analysis of DNMT3B 579 G>T genotype frequencies in esophagus cancer patients and controls, adjusted OR (95% CI)

Variable	TT genotype Case/control	GT + GG genotype Case/control	Odds ratios of GT + GG genotype
Age
< 60	81/89	24/18	1.47 (0.74-2.90)
≥ 60	70/80	19/23	0.94 (0.48-1.88)
Sex
Male	116/120	34/26	1.35 (0.76-2.39)
Female	35/49	9/15	0.84 (0.33-2.14)