Fan H, Liu DS, Zhang SH, Hu JB, Zhang F, Zhao ZJ. DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese. World J Gastroenterol 2008; 14(14): 2230-2234 [PMID: 18407600 DOI: 10.3748/wjg.14.2230]
Corresponding Author of This Article
Hong Fan, Key Laboratory of Develo-pmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, Jiangsu Province, China. fanh@seu.edu.cn
Article-Type of This Article
Rapid Communication
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hong Fan, Dong-Sheng Liu, Feng Zhang, Zhu-Jiang Zhao, Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, Jiangsu Province, China
Hong Fan, Zhu-Jiang Zhao, Department of Genetics & Developmental Biology, School of Basic Medical Sciences, Southeast University, Nanjing 210009, Jiangsu Province, China
Shu-Hong Zhang, School of Medicine, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China
Jia-Bo Hu, School of Medicine, Jiangsu University, 212001, Zhenjiang 212001, Jiangsu Province, China
Author contributions: Fan H designed the research and wrote the paper; Liu DS, Zhang SH and Hu JB performed the research; Zhang F and Zhao ZJ contributed to new reagents/analytic tools; Liu DS analyzed the data.
Correspondence to: Hong Fan, Key Laboratory of Develo-pmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, Jiangsu Province, China. fanh@seu.edu.cn
Telephone: +86-25-83272314
Fax: +86-25-83220761
Received: December 6, 2007 Revised: February 4, 2008 Published online: April 14, 2008
Abstract
AIM: To investigate the relationship between 579 G>T polymorphisms in the DNMT3B gene, which is involved in de novo methylation and associated with the risk of esophagus cancer (EC) in Chinese.
METHODS: DNMT3B 579 G>T genotypes were determined by PCR-RFLP in 194 EC patients and 210 healthy controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed EC.
RESULTS: In control subjects, the frequency of T/T and G/T genotypes, and T and G alleles was 80.5%, 19.0%, 90.0% and 10.0%, respectively. The distribution of genotypes and allelotypes in the EC patients was not significantly different from that in the controls. When stratified by sex and age, there was still no significant association between the risks of EC and GT and GG genotypes. This study also showed a distinct difference in the distribution of DNMT3B and single nucleotide polymorphism (SNP) between Chinese and Koreans.
CONCLUSION: DNMT3B 579 G>T polymorphism may not be a stratification marker to predict the susceptibility to EC, at least in Chinese. DNMT3B promoter SNP is diverse in ethnic populations.
