Yuan Y, Shimizu I, Shen M, Aoyagi E, Takenaka H, Itagaki T, Urata M, Sannomiya K, Kohno N, Tamaki K, Shono M, Takayama T. Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C. World J Gastroenterol 2008; 14(14): 2200-2207 [PMID: 18407594 DOI: 10.3748/wjg.14.2200]
Corresponding Author of This Article
Ichiro Shimizu, MD, Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto-cho, Tokushima 7708503, Japan. shimizui@clin.med.tokushima-u.ac.jp
Article-Type of This Article
Rapid Communication
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World J Gastroenterol. Apr 14, 2008; 14(14): 2200-2207 Published online Apr 14, 2008. doi: 10.3748/wjg.14.2200
Table 1 Characteristics at the time of isolation of PBMCs from age-matched younger and older males and pre- and post-menopausal females of patients with chronic hepatitis C and healthy controls
Patients with chronic hepatitis C
Healthy controls
Males (yr)
Females (yr)
Males (yr)
Females (yr)
< 50
≥ 50
< 50
≥ 50
< 50
≥ 50
< 50
≥ 50
n
18
18
17
18
18
18
18
18
Age (yr)
41 ± 7
69 ± 6
41 ± 7
68 ± 6
40 ± 6
68 ± 6
40 ± 6
69 ± 6
HCV-RNA (log copies/mL)
6.1 ± 0.8
6.5 ± 1.4
5.9 ± 0.8
6.4 ± 1.2
ND
ND
ND
ND
ALT (U/L)
118 ± 68
112 ± 52
105 ± 49
101 ± 55
27 ± 8
26 ± 8
24 ± 7
24 ± 8
Platelet count (103/mm3)
208 ± 58
189 ± 52
206 ± 54
185 ± 55
230 ± 60
219 ± 53
225 ± 57
214 ± 58
Table 2 Spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by PBMCs from age-matched younger and older males and pre- and post-menopausal females of patients with chronic hepatitis C and healthy controls (pg/mL supernatant)
Table 3 Effects of E2 and progesterone on spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by unstimulated PBMCs from age-matched older male and post-menopausal female patients with chronic hepatitis C (% of initial value)
Table 4 Effects of E2 and progesterone on hydrogen peroxide-stimulated production of TNF-α, IL-1β, IL-8, and MCP-1 by PBMCs from age-matched younger male and pre-menopausal female healthy controls (pg/mL supernatant)
Citation: Yuan Y, Shimizu I, Shen M, Aoyagi E, Takenaka H, Itagaki T, Urata M, Sannomiya K, Kohno N, Tamaki K, Shono M, Takayama T. Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C. World J Gastroenterol 2008; 14(14): 2200-2207