Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Mar 28, 2008; 14(12): 1823-1827
Published online Mar 28, 2008. doi: 10.3748/wjg.14.1823
Table 1 β-catenin target genes related to cancer
FunctionTarget gene
Cell proliferationC-myc; Cyclin D1
Inhibition of apoptosisMDR1/PGP; COX-2; PPARδ
Tumor progressionMMPs; uPAR,Upa; CD44; Laminin γ2; Nr-CAM
Growth factorsc-met; VEGF; WISP-1; BMP-4
Transcription factorsc-jun, fra-1; ITF-2; Id2; AF17
Negative feedback targetsConductin; Tcf-1; Nkd