Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?

Table 1 Description of the results of 6 studies in which intragastric injection of Botulinum Toxin type A was administered to obese patients for treatment of obesity

Reference	n	Design	Dose (UI)	Follow-up (wk)	Results
Garcia-Compean[23]	12	Pilot	100	12	Reduction of body weight: No
			antrum		Gastric emptying: Negative
Albani[24]	8	Pilot	100	16	Reduction of body weight: No
			antrum
Cardoso[25]	12	Pilot	200/300	12	Early satiety: Yes
			antrum		Reduction of body weight: No
					Gastric emptying: Negative
Gui[26]	14	RCT1	133/200	8	Early satiety: Yes
			vs saline		Reduction of body weight: No
			antrum		Gastric emptying: Negative
Foschi[27]	24	RCT1	200 vs	8	Early satiety: Yes
			saline		Reduction of weight: Yes
			antrum + fundus		Gastric emptying: Positive
					Max. gastric capacity for liquids: Positive
Mittermaier[28]	10	RCT	200 vs	24	Early satiety: No
			saline /antrum		Reduction of weight: No

¹RCT: Randomized controlled trials.