Therapeutic effects of Caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis

Table 1 Serum IL-1β levels and W/D ratios of the lungs in rats with SAP (mean ± SD)

Group	n	IL-1β (pg/mL)	W/D ratio of lung (g/g)
HC	6	90.13 ± 21.13	4.32 ± 0.33
SAP-S
6 h	6	276.77 ± 44.92b	4.85 ± 0.38a
12 h	6	308.99 ± 34.95b	4.97 ± 0.47b
18 h	5	311.60 ± 46.51b	5.03 ± 0.46b
SAP-ICE-I
6 h	6	151.42 ± 27.26bd	4.38 ± 0.36c
12 h	6	152.47 ± 29.60bd	4.48 ± 0.37c
18 h	6	175.45 ± 29.72bd	4.51 ± 0.36c

^aP < 0.05,

^bP < 0.01 vs HC group;

^cP < 0.05,

^dP < 0.01 vs SAP-S group.

Table 2 Intrapulmonary expression of Caspase-1, IL-1β and IL-18 mRNA in rats with SAP (mean ± SD)

Group	n	Caspase-1 mRNA	IL-1β mRNA	IL-18 mRNA
HC	6	0.57 ± 0.06	0.42 ± 0.03	0.55 ± 0.05
SAP-S
6 h	6	0.71 ± 0.04b	0.75 ± 0.05b	0.82 ± 0.05b
12 h	6	0.71 ± 0.05b	0.81 ± 0.06b	0.83 ± 0.06b
18 h	5	0.72 ± 0.04b	0.79 ± 0.07b	0.82 ± 0.07b
SAP-ICE-I
6 h	6	0.72 ± 0.05b	0.52 ± 0.05bd	0.58 ± 0.06d
12 h	6	0.72 ± 0.06b	0.50 ± 0.04bd	0.55 ± 0.04d
18 h	6	0.69 ± 0.08b	0.49 ± 0.04ad	0.57 ± 0.04d

^aP < 0.05,

^bP < 0.01 vs HC group; ^cP < 0.05,

^dP < 0.01 vs SAP-S group.