Thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouraci-based adjuvant chemotherapy for gastric cancer

Table 1 Relationship between TS/TP mRNA levels and clinicopathologic factors

Factor	n	TS		P	TP		P
		High value	Low value	value	High value	Low value	value
Age (yr)
≥ 60	22	9	13	0.313	12	10	0.492
< 60	29	16	13		13	16
Gender
Male	39	19	20	0.938	18	21	0.460
Female	12	6	6		7	5
Histological Type
II	25	15	10	0.124	11	14	0.482
III	26	10	16		14	12
Lymphatic metastasis
Positive	41	22	19	0.323	21	20	0.777
Negative	10	3	7		4	6

TS: thymidylate synthase; TP: thymidine phosphorylase.

Table 2 Coupled expression of TS + TP and patients survival

	TS + TP		P-value
	High value	Low value
n	16	17
DFS	8.3 (3.7-23.7)	16.2 (5.8-30.7)	0.013
OS	16.2 (5.3-29.7)	25.0 (9.2-32.1)	0.003

DFS: disease-free survival; OS: overall survival; TS: thymidylate synthase; TP: thymidine phosphorylase.