Gastric Cancer
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 7, 2007; 13(29): 3925-3931
Published online Aug 7, 2007. doi: 10.3748/wjg.v13.i29.3925
Table 1 Membranous and cytoplasmic expression of E-cadherin in EBV-GCs and non EBV-GCs
Location of E-cadherin expressionNumber of the cases (%)
OR195% CI1
EBV-GCsnon EBV-GCs
Total59120
Membranous
Preserved (> 50%)14 (24)29 (24)1Referent
Lost (< 50%)45 (76)91 (76)0.990.48-2.05
Cytoplasm
Negative26 (44)59 (49)1Referent
Positive (subtotal)33 (56)61 (51)1.280.65-2.50
10%-17 (29)29 (24)1.370.62-3.01
50%-11 (19)29 (24)0.920.39-2.18
90%-5 (8)3 (3)3.980.88-18.0
P = 0.374
Table 2 Membranous and nuclear and/or cytoplasmic expression of beta-catenin in EBV-GCs and non EBV-GCs
Location ofbeta-catenin expressionNumber of the cases (%)
OR195% CI1
EBV-GCsnon EBV-GCs
Total59120
Membranous
Preserved (> 10%)49 (83)78 (65)1Referent
Lost (< 10%)10 (17)42 (35)0.410.19-0.90
Nuclei and cytoplasm
Negative46 (78)106 (88)1Referent
Positive (subtotal)13 (22)14 (12)2.230.97-5.09
10%-5 (8)8 (7)1.480.47-4.66
50%-6 (10)6 (5)2.340.74-7.36
90%-2 (3)0 (0)-
P = 0.024
Table 3 Results of survival analysis in EBV-GC and non EBV-GC cases
Non EBV-GCs
EBV GCs
Death1/Total (%)HR295% CI2Death1/Total (%)HR295% CI2
Depth
m, sm6/29 (21)1Referent3/13 (23)1Referent
pm3/13 (23)0.760.19-3.072/8 (25)1.640.23-11.9
s, ss, se37/58 (64)2.030.74-5.5318/28 (64)6.031.39-26.2
P = 0.112P = 0.005
Lymph node metastasis
010/51 (20)1Referent13/32 (41)1Referent
116/26 (62)3.551.44-8.774/9 (44)2.130.57-7.94
2+20/23 (87)6.832.75-17.06/8 (75)7.771.93-31.3
P < 0.001P = 0.004
Lauren classification
Diffuse14/30 (47)1Referent6/20 (30)1Referent
Intestinal32/70 (46)1.100.55-2.0217/29 (59)9.472.67-33.6
P = 0.865P < 0.001
p53
Negative21/52 (40)1Referent13/26 (50)1Referent
Positive25/48 (52)1.600.87-2.9110/23 (43)1.290.50-3.30
P = 0.127P = 0.595
E-cadherin in membrane
Preserved9/28 (32)1Referent6/12 (50)1Referent
Lost37/72 (51)1.500.70-3.2217/37 (46)0.730.25-2.12
P = 0.276P = 0.568
E-cadherin in nuclei and/or cytoplasm
Negative30/62 (48)1Referent12/26 (46)1Referent
Positive16/38 (42)0.560.30-1.0611/23 (48)1.370.56-3.34
P = 0.071P = 0.481
Beta-catenin in membrane
Preserved28/64 (44)1Referent19/43 (44)1Referent
Lost18/36 (50)1.100.57-2.114/6 (67)1.390.42-4.60
P = 0.778P = 0.601
Beta-catenin in nuclei and/or cytoplasm
Negative41/89 (20)1Referent18/37 (49)1Referent
Positive5/11 (45)0.810.31-2.095/12 (42)0.320.11-0.93
P = 0.654P = 0.028