Viral Hepatitis
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 21, 2007; 13(27): 3677-3683
Published online Jul 21, 2007. doi: 10.3748/wjg.v13.i27.3677
Table 1 Enrolled subjects: main findings (mean ± SD)
ControlsHCV-positive CH patients
Total number50114
M/F26/2459/55
Median age, yr (range)53 (26-74)54 (22-81)
ALT (IU/L, nv < 40)12 ± 1190.2 ± 60.4
γGT (IU/L, nv < 50)28 ± 977 ± 52
Total proteins (g/dL)6.8 ± 2.77.2 ± 1.2
Albumin (g/dL)4.1 ± 1.23.6 ± 0.8
Total bilirubin (mg/dL)0.8 ± 0.30.9 ± 0.3
Prothrombin time (s)10.3 ± 2.110.5 ± 2.3
Platelets (n x 103/μL)278 ± 89159 ± 52
Ishak score for grading (median and range)-9 (5-11)
Ishak score for staging-3 (2-3)
(median and range)
Table 2 Plasma parameters (mean ± SD)
HCV-infected patients
ControlsCH (all patients)CH with platelets > 150 000/μLCH with platelets < 150 000/μL
Nitrite (μmol/L)6.51 ± 4.647.98 ± 3.925.78 ± 2.0310.64 ± 3.51ab
NPSH (μmol/L)367 ± 24323 ± 26372 ± 28254 ± 21bd
GSH (μmol/L)8.1 ± 2.47.3 ± 3.58.8 ± 2.62.7 ± 1.0bd
CYS (μmol/L)17 ± 4.114 ± 5.216.8 ± 5.210 ± 2.9bd
S-NO (μmol/L)7.4 ± 1.527.9 ± 8.4b33.8 ± 7.5b21.4 ± 6.9ab
MDA (μmol/L)0.28 ± 0.050.25 ± 0.900.21 ± 0.180.46 ± 0.13ab
4-HNE (μmol/L)0.20 ± 0.080.24 ± 0.120.29 ± 0.110.59 ± 0.31bd
TNFα (pg/mL)26.7 ± 9.129.9 ± 5.736.4 ± 3.1b26.2 ± 3.9d
IL-6 (pg/mL)28.9 ± 7.331 ± 6.146.4 ± 3.1b26.5 ± 6.4d
Score of fibrosis (median and range)02 (1-4)2 (1-2)3 (2-4)a
HCV-RNA (× 106 UI/mL)06.24 ± 1.385.48 ± 1.326.18 ± 2.1