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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 21, 2007; 13(23): 3221-3227
Published online Jun 21, 2007. doi: 10.3748/wjg.v13.i23.3221
Published online Jun 21, 2007. doi: 10.3748/wjg.v13.i23.3221
Table 1 Clinico-pathological and biological parameters of patients
| Characteristics | n (%) | Deaths, n (%) | RR (95% CI) |
| Males | 26 (83.9) | 14 (53.8) | 1.14 (0.36-3.57) |
| Age < 65 yr | 21 (67.7) | 12 (57.1) | 1 (0.37-2.70) |
| Cirrhosis | 29 (93.5) | 18 (62) | 21.85 (0-187.50) |
| HCV (+) | 16 (51.6) | 10 (62.5) | 0.80 (0.31-2.06) |
| Alcohol etiology | 13 (42.0) | 11 (84.6) | 0.62 (0.23-1.62) |
| Uninodular | 25 (80.6) | 15 (60) | 1.33 (0.37-4.74) |
| Size ≤ median mm | 21 (67.7) | 10 (47.6) | 4.73 (1.61-13.89)a |
| Alpha-fetoprotein ≥ 20 (ng/mL) | 12 (38.7) | 8 (66.6) | 1.46 (0.57-3.71) |
| Histopathology HCC-T | 28 (90.3) | 16 (55.1) | 1.35 (0.30-5.95) |
| AR (+) | 21 (67.7) | 10 (47.6) | 0.62 (0.25-1.68) |
| ER (+) | 16 (51.6) | 10 (62.5) | 1.05 (0.41-2.67) |
| PgR (+) | 26 (83.9) | 13 (50) | 0.26 (0.08-0.85)a |
| ApoD (+) | 12 (38.7) | 8 (66.6) | 1.47 (0.57-3.77) |
Table 2 Relationship between AR and ER Immunostaining values and Clinico-Pathological Characteristics
| Characteristics | Androgen receptors (AR) | Estrogen receptors (ER) | ||
| n (%) | Score valuesmedian (range) | n (%) | Score valuesmedian (range) | |
| Males | 18 (69.2) | 4.1 (0-229.5) | 12 (46.2) | 8.5 (0-65) |
| Age < 65 yr | 15 (71.4) | 6.7 (0-52) | 10 (47.6) | 8.5 (0-65) |
| Cirrhosis | 19 (65.5) | 4.2 (0-229.5) | 16 (55.2) | 8.5 (0-65) |
| VHC (+) | 11 (68.8) | 4.2 (0-229.5) | 11 (68.8) | 8.75 (0-65) |
| Alcohol etiology | 7 (53.8) | 3.7 (0-52) | 3 (23.1) | 0 (0-65) |
| Uninodular | 16 (64) | 4.2 (0-229.5) | 13 (52) | 8.5 (0-65) |
| Tumor size | ||||
| < median | 13 (61.9) | 4 (0-229.5) | 12 (57.1) | 8.5 (0-65) |
| ≥ median | 8 (80) | 5.75 (0-16) | 4 (40) | 8.7 (0-15.75) |
| Alfa-fetoprotein (ng/mL) | ||||
| < 20 | 12 (63.2) | 4 (0-229.5) | 8 (42.1) | 8.5 (0-65) |
| ≥ 20 | 9 (75) | 5.7 (0-31) | 8 (66.7) | 8.7 (0-16) |
| Histopathology | ||||
| HCC-T | 20 (71.4) | 4.5 (0-229.5) | 15 (53.6) | 8.5 (0-65) |
| Non HCC-T | 1 (33.3) | 1 (0-26.25) | 1 (33.3) | 0 (0-20.5) |
| Death | ||||
| No | 11 (84.6) | 12 (0-229.5) | 6 (46.2) | 9 (0-65) |
| Yes | 10 (55.6) | 4 (0-28.75) | 10 (55.6) | 8.5 (0-20.5) |
| Androgen receptors | ||||
| Negative | - | - | 3 (30) | 0 (0-20.5)a |
| Positive | 13 (61.9) | 9 (0-65) | ||
| Estrogen receptors | ||||
| Negative | 8 (53.3) | 3.2 (0-29) | - | - |
| Positive | 13 (81.3) | 8.4 (0-229.5) | ||
| Progesterone receptors | ||||
| Negative | 0 (0)c | 1.7 (0-4.2)a | 1 (20) | 0 (0-8.5)a |
| Positive | 21 (80.8) | 8.4 (0-229.5) | 15 (57.7) | 9 (0-65) |
| Apo D | ||||
| Negative | 13 (68.4) | 4.2 (0-52) | 10 (52.6) | 8.5 (0-65) |
| Positive | 8 (66.7) | 4.2 (0-229.5) | 6 (50) | 8.5 (0-65) |
Table 3 Relationship between PgR and Apo D Immunostaining values and clinico-pathological characteristics
| Progesterone receptors (PgR) | Apolipoprotein-D (Apo D) | |||
| Characteristics | n (%) | Score(median-range) | n (%) | Score(median-range) |
| Males | 22 (84.6) | 13.7 (0-61) | 10 (28.5) | 0 (0-81.1) |
| Age < 65 yr | 17 (81) | 9.7 (0-61) | 7 (33.3) | 0 (0-69.5) |
| Cirrhosis | 24 (82.8) | 14 (0-61) | 11 (37.9) | 0 (0-81.1) |
| HCV (+) | 15 (93.8) | 15.9 (3-61) | 8 (50) | 11 (0-81.11) |
| Alcohol etiology | 11 (84.6) | 9.7 (0-25) | 5 (38.5%) | 0 (0-80.4) |
| Uninodular | 20 (80) | 13.7 (0-61) | 11 (44) | 0 (0-81.1) |
| Size < median | 17 (81) | 13.7 (0-61) | 6 (28.6) | 0 (0-80.4) |
| Alfa-fetoprotein ≥ | ||||
| 20 (ng/mL) | 11 (91.7) | 14 (5.7-61) | 3 (25) | 0 (0-80.4) |
| Histopathology | ||||
| HCC-T | 23 (82.1) | 13.7 (0-61) | 11 (39.3) | 0 (0-81.1) |
| Death rate | 13 (72.2) | 11.75 (0-61) | 8 (44.4) | 0 (0-81.1) |
| Androgen receptors | ||||
| Negative | 5 (50)c | 9.6 (0-20)a | 4 (40) | 0 (0-80.4) |
| Positive | 21 (100) | 14.2 (4-61) | 8 (38.1) | 0 (0-81.1) |
| Estrogen receptors | ||||
| Negative | 11 (73.3) | 8 (0-34)a | 6 (40) | 0 (0-81.1) |
| Positive | 15 (93.8) | 17.2 (3-61) | 6 (37.5) | 0 (0-80.4) |
| Pg receptors | ||||
| Negative | - | - | 2 (40) | 0 (0-24.4) |
| Positive | 10 (38.5) | 0 (0-81.1) | ||
| ApoD | ||||
| Negative | 16 (84.2) | 13.7 (0-61) | - | - |
| Positive | 10 (83.3) | 13.8 (3-34) | ||
- Citation: Vizoso F, Rodriguez M, Altadill A, González-Diéguez M, Linares A, González L, Junquera S, Fresno-Forcelledo F, Corte M, Rodrigo L. Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma. World J Gastroenterol 2007; 13(23): 3221-3227
- URL: https://www.wjgnet.com/1007-9327/full/v13/i23/3221.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i23.3221