Clinical features of familial adenomas polyps in Chinese and establishment of its immortal lymphocyte cell lines

Table 1 Phenotype of different kinds of FAP families mean ± SD

Kinds of FAP families	Number of families	Families withpositivefamily history	Mean number ofcolorectal neoplasmsb	Mean number ofcolorectal cancer	Mean of the earliest age atdiagnosis in one family
CFAP	21	16	3.14 ± 1.59	1.29 ± 1.10	32.9 ± 10.31
AFAP	3	3	2.00 ± 0.00	1.50 ± 0.71	42.0 ± 14.0
Suspected AFAP	3	3	2.67 ± 0.58	0.67 ± 0.58	25.0 ± 3.61

CFAP: Classical familial adenomatous polyposisp; AFAP: attenuated familial adenomatous polyposisp.

^bP < 0.01, comparison between CFAP and AFAP.

Table 2 Phenotype of different kinds of FAP families

Kinds of FAP families	Mean of the latest age atdiagnosis in one familyb	Mean age ofsymptom appearing	Mean age of colorectalcancer developmentb	Extra coloniccancers/colorectal neoplasms	Positive CHRPEfamilies/total checked families
CFAP	41.75 ± 7.75	26.56 ± 12.36	42.23 ± 9.24	6/66	11/12
AFAP	58.67 ± 7.37	37.50 ± 21.92	57.33 ± 8.39	2/6	2/2
Suspected AFAP	41.6 ± 10.02	18.00 ± 4.24	33.67 ± 13.58	0	2/2

CFAP: Classical familial adenomatous polyposisp; AFAP: attenuated familial adenomatous polyposisp.

^bP < 0.01, comparison between CFAP and AFAP.

Table 3 Phenotype in FAP families with a different family history mean ± SD

Status of family history	Number of families	Mean number ofcolorectal neoplasmsb	Mean number ofcolorectal cancers	Mean of the youngest age atdiagnosis of FAP in one familyb
Positive	22	3.41 ± 1.22	1.68 ± 0.82	29.95 ± 8.25
Negaitive	5	1.00 ± 0.00	0	46.80 ± 9.91

^bP < 0.01, comparison between CFAP and AFAP.

Table 4 Phenotype in FAP families with different family history mean ± SD

Status offamily history	Mean of the latest age atdiagnosis in one family	Mean age ofsymptom appearing	Mean age of colorectalcancer development	Extra coloniccancers/colorectal neoplasmsb	Positive CHRPE families/totalchecked families
Positive	44.05 ± 9.64	25.64 ± 12.36	43.15 ± 11.48	5/75	12/13
Negaitive		33.33 ± 17.01		3/5	3/3

^bP < 0.01, comparison between CFAP and AFAP.