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Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. May 7, 2007; 13(17): 2406-2415
Published online May 7, 2007. doi: 10.3748/wjg.v13.i17.2406
Table 1 Viral proteins and their functions in HCV life cycle
ProteinMolecular Mass1Function
Core21 kDaRNA binding; nucleocapsid
E131-35 kDaEnvelope glycoprotein; associate with E2
E270 kDaEnvelope glycoprotein; receptor binding; associate with E1
p77 kDaIon channel
NS221 kDaComponent of NS2-3 proteinase
NS369 kDaN-terminal proteinase domain;
C-terminal NTPase/helicase domain
NS4A6 kDaNS3-4A proteinase cofactor
NS4B27 kDaInduces membrane alterations
NS5A56-58 kDaPhosphoprotein
NS5B68 kDaRNA-dependent RNA polymerase