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World J Gastroenterol. May 7, 2007; 13(17): 2406-2415
Published online May 7, 2007. doi: 10.3748/wjg.v13.i17.2406
Hepatitis C virus proteins
Jean Dubuisson
Jean Dubuisson, Institut de Biologie de Lille (UMR8161), CNRS, Université de Lille I & II and Institut Pasteur de Lille, Lille, France
Author contributions: All authors contributed equally to the work.
Correspondence to: Jean Dubuisson, DVM, PhD, Hepatitis C Laboratory, CNRS-UMR8161, Institut de Biologie de Lille, 1 rue Calmette, BP447, 59021 Lille Cedex, France.
Telephone: +33-3-20871160 Fax: +33-3-20871201
Received: December 23, 2006
Revised: December 28, 2006
Accepted: February 14, 2007
Published online: May 7, 2007

Hepatitis C virus (HCV) encodes a single polyprotein, which is processed by cellular and viral proteases to generate 10 polypeptides. The HCV genome also contains an overlapping +1 reading frame that may lead to the synthesis of an additional protein. Until recently, studies of HCV have been hampered by the lack of a productive cell culture system. Since the identification of HCV genome approximately 17 years ago, structural, biochemical and biological information on HCV proteins has mainly been obtained with proteins produced by heterologous expression systems. In addition, some functional studies have also been confirmed with replicon systems or with retroviral particles pseudotyped with HCV envelope glycoproteins. The data that have accumulated on HCV proteins begin to provide a framework for understanding the molecular mechanisms involved in the major steps of HCV life cycle. Moreover, the knowledge accumulated on HCV proteins is also leading to the development of antiviral drugs among which some are showing promising results in early-phase clinical trials. This review summarizes the current knowledge on the functions and biochemical features of HCV proteins.

Keywords: Hepatitis C virus, Viral hepatitis, Viral proteins, Molecular virology