Hepatitis B virus taxonomy and hepatitis B virus genotypes

Table 1 Orthohepadnaviruses and their host

	Host	Ref.
Hepatitis B Virus	Man	[75]
	Homo sapiens sapiens
Chimpanzee Hepatitis B Virus	Chimpanzee	[76]
	Pan troglodytes
Gibbon Hepatitis B Virus	White handed gibbon	[77]
	Hylobates lar
Orangutan Hepatitis B Virus	Orangutan	[78]
	Pongo pygmaeuspygmaeus
Gorilla Hepatitis B Virus	Gorilla	[79]
	Gorilla gorilla
Woolly Monkey Hepatitis B Virus	Woolly monkey	[80]
	Lagothrix lagotricha
Woodchuck Hepatitis Virus	Woodchuck	[19]
	Marmota monax
Ground Squirrel Hepatitis Virus	Ground Squirrel	[20]
	Spermophilus beecheyi
Arctic Squirrel Hepatitis Virus	Arctic Squirrel	[81]
	Spermophylus parryikennicotti

Table 2 Avihepadnaviruses and their host

	Host	Ref.
Duck Hepatitis B Virus	Pekin duck	[21]
DHBV	Anas domesticus
Grey Teal Hepatitis B Virus	Grey Teal	[82]
(GTHBV)	Anas gibberifrons gracilis
Heron Hepatitis B Virus	Heron	[83]
(HHBV)	Adrea cinerea
Maned Duck Hepatitis B Virus	Maned Duck	[82]
(MDHBV)	Chenonetta jubata
Ross Goose Hepatitis Virus	Ross Goose	[4]
(RGHV)	Anser rossi
Snow Goose Hepatitis B Virus	Snow Goose	[84]
(SGHBV)	Anser caerulescens
Stork Hepatitis B Virus	White Stork	[85]
(STHBV)	Ciconia ciconia
	Demoiselle cranes	[86]
Crane Hepatitis B Virus	Anthropoides virgo
(CHBV)	Grey crowned cranes
	Balearica regulorum

Table 3 Fundamental properties of genomes and differences between HBV genotypes

Genotype	Genome length in bp	ORF-differences
A	3221	Insertion of aa 153 and 154 in HBc
B	3215
C	3215
D	3182	Deletion of aa 1-11 in preS1
E	3212	Deletion of aa 11 in preS1
F	3215
G	3248	Insertion of 12 aa in HBc
		Deletion of aa 11 in preS1
H	3215

Table 4 HBV subgenotypes and geographic prevalence

	Subgenotype	Synonyms	Geographic origin	Ref.
A	A1	Aa, A’	Africa, (Asia, South America)	[41,87]
	A2	Ae, A-A'	Europe
	A3	Ac	Gabon, Cameroon	[88,89]
	(A4)		Mali	[59]
	(A5)		Nigeria	[59]
B	B1	Bj	Japan	[67,90]
	B2	Ba	Asia without Japan
	B3		Indonesia, Philippines	[7]
	B4		Vietnam	[7]
	B5		Philippines	[91,92]
C	C1	Cs	South East Asia (Vietnam, Myanmar, Thailand, Southern China)	[37-39]
	C2	Ce	Far East (Korea, Japan, Northern China)
	C3		Micronesia	[7]
	C4		Australia	[93]
	C5		Philippines, Vietnam	[92,94]
D	D1		Mongolia, Belarus, Europe?
	D2		India?
	D3		South Africa, East India, Serbia	[40,41]
	D4		Australia	[93]
	D5		East India	[40]
F	F1		South and Central America	[95,96]
	F2		South America	[4]
	F3		Bolivia	[97,98]
	F4		Argentina	[97,98]

Table 5 Examples for recombination events between of HBV genotypes

Genotype of		Recombination Breakpoint		No.in literature	Ref.
Backbone	Insert	5’	3’
A	C	1801	2865	3	[99]
A	D	2895	327
		2820	386-586	3	[100]
		?	670
B	C	1740-1838	2443- 2485	41	[67,73,101,102]
B	C	3120	3171	1	[60]
		3060	3191	1
		2910	2950	1
C	B	1731-1838	2437- 2479	1	[102]
D	A	129	2339	3	[73,101,102]
		495	780
		822	1775
G	C	1860	2460	1	[103]
A	E	882	1060	1	[88]