Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions

Table 1 Patients characteristics and clinicopathological features of resected lesions

Gender ( male / female )	124/56
Mean age (range), years	63.0 (37-76)
Histology
Non-neoplastic ( hyperplastic / others )	24 (20/4)
Neoplastic ( mild / moderate / severe atypia / mucosal cancer )	186 (21/133/28/4)
Mean size of resected lesions ( range ), mm	9.1 (3-18)
Location ( proximal / distal )	91/119
Meantime to cecum ( range ), min	8.3 (1-23)
Mean time for diagnosis and treatment ( range ), min	22.5 (5-45)

Table 2 Correlation of endoscopic diagnosis and histological diagnosis in this study

Histological diagnosis
Endoscopic diagnosis	Non-neoplastic	Neoplastic	Total	Diagnostic accuracy
Type I-II	24	0	24	100%
Type III-V	2	184	186	99.8%
Total	26	184	210

Table 3 Summaries of the previous reports and this study on overall diagnostic accuracy, sensitivity, specificity and predictive values in differentiating non-neoplastic lesions from neoplastic ones

Author	Method	Number of lesions	Overall accuracy ( % )	Sensitivity ( % )	Specificity ( % )	PPV1 ( % )	NPV2 ( % )
Chapius	Ordinary	120	82.5	84.5	77.7	89.8	68.3
Neale	Ordinary	181	80.2	69.2	85.4	69.2	85.5
Konishi	Ordinary	407	68	90	61	94.4	85.1
Fu	Ordinary	206	84.0	88.8	67.4	93.4	63.3
Eisen	Chromoendoscopy	480	82.1	82	82	75	88
Kiesslich	Chromoendoscopy	283	92.6	92.4	93.2	97.5	81
Fu	Chromoendoscopy	206	89.3	93.1	76.1	93.1	76.1
Axelard	Magnifying	55	94.5	92.9	95.1	86.7	97.5
Togashi	Magnifying	923	88.4	92	73.3	94.2	85.2
Tung	Magnifying	175	80.6	93.8	64.6	76.3	89.5
Liu	Magnifying	954	86.1	90.8	72.7	90.4	73.6
Konishi	Magnifying	405	92	97	100	96.3	86.5
Fu	Magnifying	206	95.6	96.3	93.5	98.1	87.8
Hurlstone	Magnifying	1008	95	98	92	95	96
This study	Magnifying	210	99.1	92	100	100	99.8

¹PPV: positive predictive value,

²NPV: negative predictive value