In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury

Table 1 Effect of GLPG on liver weight in mice with CCl₄-induced hepatic injury after 72 h (mean ± SD)

Group	Liver weight (g)
Control	1.77  ±  0.26
GLPG (500 mg/kg)	1.74 ± 0.21
CCl4 (1600 mg/kg)	2.22 ± 0.34
CCl4 (1600 mg/kg) + GLPG(300 mg/kg)	1.67 ± 0.17
CCl4 (1600 mg/kg) + GLPG(600 mg/kg)	1.57 ± 0.18
CCl4 (1600 mg/kg) + GLPG(900 mg/kg)	1.52 ± 0.14

^aP<0.05 vs CCl₄-treatment group; ^bP<0.01 vs control group; n=10 mice.

Table 2 Effects of GLPG on ALT and AST activities in mice with CCl₄-induced hepatic injury after 24 h and 72 h (mean±SD)

Group	ALT(U/L)		AST(U/L)
	24h	72h	24h	72h
Control	54.38 ± 6.20	-	44.50 ± 34.36	-
GLPG	74.00 ± 17.14	-	51.75 ± 29.43	-
(500mg/kg)
CCl4	642.50 ± 225.33	105.00 ± 39.64	147.50 ± 58.80	180.25 ± 45.51
(1600mg/kg)
CCl4	433.38 ± 133.97b	96.56 ± 27.84	99.88 ± 40.47a	161.13 ± 18.29
(1600mg/kg)+GLPG (300mg/kg)
CCl4	374.00 ± 107.34c	87.30 ± 15.60	61.25 ± 26.50c	151.63 ± 32.67
(1600mg/kg)+GLPG(600mg/kg)
CCl4	316.50 ± 98.76c	79 .70 ± 17.28a	56.75 ± 36.58c	114.75 ± 67.13a
(1600mg/kg)+GLPG (900mg/kg)

^aP < 0.05 vs CCl₄ treatment group;

^bP< 0.01,

^cP< 0.001 vs control group; n = 20 mice.