Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer

Table 1 Background information of patients who had recurrent ulcer bleeding after surgery for peptic ulcer disease

Case	Age(yr)	Smokingstatus	H. pyloristatus	Type ofoperation	Yearssince operation	Bleedingepisodes after Surgery	Follow-up(mo)
1	62	Never	Positive1	TV+D2	5, 23	3	72
2	60	Ex-smoker	Positive	TV+D	6	8	62
3	61	Smoker	Positive1	BII	2	1	61
4	66	Never	Negative	BII+V2	4, 33	2	56
5	49	Smoker	Positive	TV+D	7	1	52
6	70	Ex-smoker	Negative	BII	18	2	43
7	64	Never	Negative	BII	3	2	35
8	59	Ex-smoker	Negative	BII	16	4	32
9	66	Smoker	Negative	TV+D	7	5	28
10	52	Ex-smoker	Positive	TV+D	5	2	18
11	48	Ex-smoker	Negative	TV+P	13	9	12

¹Successful H. pylori eradication therapy upon entering the study.

²Final operation.

³Years elapsed since the first and second gastric operation, upon entering the study. TV+D: truncal vagotomy and gastrojejunostomy. TV+P: truncal vagotomy and pyloroplasty. BII: Billroth II partial gastrectomy.

Table 2 Demographic data of patients and control groups and results (median, range) of the 24-h fraction (%) time of gastric pH <4 before (basal) and while on 20 mg/d omeprazole.

Groups studied	Numberofpatients	Age(yr)	H pylori(+)	Treatment-free(baseline)	Omeprazole20 mg/d	Pvalue
Normal controls	10	60, 47 – 73	2/9	87.7, 71.3 – 98.5	34.6, 4.3 – 72.7	<0.001
Duodenal ulcer controls	7	61, 38 – 71	7/7	92.3, 86.6 – 98.8	45.2, 25.8 – 72.0	0.002
Vagotomy controls2	7	54, 41 – 72	2/6	72.8, 34.0 – 87.3	17.8, 6.5 – 35.1	0.005
Gastrectomy controls	7	66, 46 – 72	1/7	6.2, 4.6 – 39.6	ND1
Vagotomy patients	5	57, 49 – 72	3/5	84.9, 79.1– 95.2	49.4, 18.3 – 69.9	0.012
Gastrectomy patients	5	68, 61 – 72	0/5	69.8, 45.8	– 85.2 28.8, 13.3 – 51.3	0.037

¹ND, not done.

²Truncal vagotomy and gastrojejunostomy (n = 5), truncal vagotomy and pyloroplasty (n = 2)