High serum leptin is an independent risk factor for non-response patients with low viremia to antiviral treatment in chronic hepatitis C

Table 1 Demography of chronic hepatitis C patients and comparison between NR and SR to interferon

	Total	NR	SR	P value
	(n = 139)	(n = 106)	(n = 33)
Age (yr)	49.9 ± 11.1	70:30:00	25:06:00	NS
Sex (male:female)	87:54:00	62:44:00	25:08:00	NS
HCV RNA load	50:89	1.015972222	27:06:00	< 0.0001
(< 100 U/L:≥ 100 U/L)
Serotype (1:2)	99:40:00	81:25:00	18:15	0.026
Alcohol intake (yes:no)	0.424305556	0.319444444	2:31	NS
Complication of	0.50625	0.319444444	4:29	NS
diabetes mellitus (yes:no)
Body mass index (< 25:≥ 25)	108:31:00	80:26:00	28:05:00	NS
Leptin (<  8 μg/L:≥ 8 μg/L)	91:48:00	63:43:00	25:03:00	0.017
Pathological findings
Grading (A0, A1:A2, A3)	28:111	0.810416667	9:23	NS
Staging (F0, F1:F2, F3)	52:87	34:71	1	17:15
Steatosis (grade 1, 2:3, 4)	93:46:00	69:36:00	23:09	NS

Table 2 Multivariate analysis of parameters

		P	Odds ratio	RR (95%CI)
independently influenced SR (n = 33)	Serotype	0.93	1.05	(0.34-3.32)
	HCV RNA	< 0.0001	12.74	(4.15-39.08)
	Fibrosis	0.18	0.49	(0.18-1.39)
	Leptin level	0.14	2.87	(0.18-11.63)
50 subjects with low viremia level	Serotype	0.95	0.25	(0.25-3.63)
	Fibrosis	0.14	0.37	(0.1-1.4)
	Leptin level	< 0.05	9.38	(0.99-88.85)