Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated withchemo-radiotherapy

Table 1 Characteristics of the patients

Baseline factors	n (%) )
Sex
Male	32 (73)
Female	12 (27)
Age (yr)
≤ 50	16 (36)
51-64	13 (30)
≥ 65	15 (34)
Median (Range)	60 (33-77)
Stage at diagnostic
I-II	14 (32)
IIIA + IIIB	21 (48)
IV	9 (20)
Histotype
Intestinal	9 (20)
Diffuse	35 (80)
Grading
I	3 (7)
II	8 (18)
III	33 (75)
Tumor location
Cardia	9 (21)
Fundus	9 (21)
Body	10 (24)
Antrum	14 (33)
Gastrectomy
R0	35 (80)
R1	8 (18)
R2	1 (2)
XPD 751
Lys/Lys	19 (51)
Lys/Gln	14 (38)
Gln/Gln	4 (11)
Unknown	7

Table 2 Toxicity evaluated

Toxicity grade III-IV	n (%)
No	28 (64)
Yes	16 (36)
Toxicity type
Hematological	10 (62)
Digestive	3 (19)
Others	3 (19)

Table 3 Relapse site

Relapse	n (%)
No	24 (54.5)
Yes	20 (45.5)
Relapse sites
Local	5 (25)
Distant	10 (50)
Local + Distant	5 (25)

Table 4 Results of chi-square test for disease relapse

Relapse	XPD			Stage
	Lys	Lys/Gln	Gln/Gln	I+ II	IIIA + IIIB + IV
No	7	11	3	11	13
Yes	12	3	1	3	17
P	0.042			0.050

Table 5 Unadjusted XPD genotype and relapse-free survival (RFS)

XPD	RFS (median)	Hazard Ratio	95% CI
Lys/Lys	11.79	1.0	Reference
Lys/Gln	14.33	0.35	0.11 to 1.09
Gln/Gln	23.33	0.25	0.03 to 1.96

Table 6 Adjusted Cox multivariate analysis for RFS

XPD	RFS (median)	Hazard Ratio	95% CI	P
Lys/Lys	11.79	3.07	1.07 to 8.78	0.036
Lys/Gln + Gln/Gln	20.26	1.0	Reference