Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats

Table 1 Effect of BPB on gastric secretion and acidity in 6 h pylorus ligated rats (mean ± SE)

Treatment	Gastric secretion(mL)	Total acid output(mmol)
Control (Ligation only)	9.8 ± 0.55	663 ± 48.7
Ligation + BPB 5 mg/kg	7.4 ± 0.42b	576 ± 66.9
Ligation + BPB 15 mg/kg	6.6 ± 0.59b	193 ± 51.5b
Ligation + BPB 45 mg/kg	4.5 ± 0.47b	162 ± 34.8b

^bP < 0.01 vs control (Dunnett’s test).

Table 2 Effect of BPB on ethanol induced changes in Alcian blue binding capacity, NP-SH levels and MPO activity in gastric mucosa of rats (mean ± SE)

Treatment	Alcian blue binding(mg/g tissue)	Non-proteinsulfhydryl(mmol/g tissue)	Myeloperoxidaseactivity(△A/g tissue)
Normal	935 ± 60.5	4.26 ± 0.11	0.081 ± 0.019
Ethanol (EtOH) alone	688 ± 25.2a	2.96 ± 0.22b	0.974 ± 0.067b
EtOH + BPB 5 mg/kg	847 ± 75.8	4.08 ± 0.12d	0.123 ± 0.024d
EtOH + BPB 15 mg/kg	820 ± 70.6	4.02 ± 0.24d	0.186 ± 0.089d
EtOH + BPB 45 mg/kg	927 ± 34.2c	4.80 ± 0.19d	0.067 ± 0.025d

^aP < 0.05 and

^bP < 0.01 vs control group;

^cP < 0.05,

^dP < 0.01 vs EtOH alone (Dunnett’s test).