In vitro and in vivo effects of ferulic acid on gastrointestinal motility: Inhibition of cisplatin-induced delay in gastric emptying in rats

Table 1 Effect of ferulic acid on gastrointestinal transit rate of a semisolid charcoal meal in rats

Treatment	Dose	Transit rate(% ± SE)	% changeof control
Saline (control)	1 mL, oral	58 ± 1.5	0.0
Ferulic acid	50 mg/kg, oral	73 ± 3.1	25.9
	100 mg/kg, oral	85 ± 2.1	46.6
	200 mg/kg, oral	91 ± 3.2	56.9
Indomethacin	0.75 mg/kg, ip	51 ± 2.0	- 12.1
Indomethacin + ferulic acid	0.75 mg/kg, ip + 100 mg/kg, po	65 ± 3.3	12.1

Compounds were orally administered 60 min before the test meal (10 mL/kg body weight of 5% charcoal in 5% gum tragacanth). P < 0.05 vs control group or indomethacin group, using ANOVA followed by Bonferroni test for multiple comparisons.