In vitro and in vivo effects of ferulic acid on gastrointestinal motility: Inhibition of cisplatin-induced delay in gastric emptying in rats

doi:10.3748/wjg.v12.i33.5363

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Sep 7, 2006 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2006; 12(33): 5363-5367
Published online Sep 7, 2006. doi: 10.3748/wjg.v12.i33.5363

In vitro and in vivo effects of ferulic acid on gastrointestinal motility: Inhibition of cisplatin-induced delay in gastric emptying in rats

Osama A Badary, Azza S Awad, Mohey A Sherief, Farid MA Hamada

Osama A Badary, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt

Azza S Awad, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University (Girls), Nasr City, Cairo, Egypt

Mohey A Sherief, Department of Pharmacology, Faculty of Medicine, Benha University, Benha, Egypt

Farid MA Hamada, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt

Correspondence to: Osama A Badary, PhD, Department of Pharmacology & Toxicology, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt. obadary@yahoo.com

Telephone: +20-10-6609942 Fax: +20-2-5541601

Received: May 11, 2006
Revised: May 28, 2006
Accepted: June 14, 2006
Published online: September 7, 2006

Abstract

AIM: To study the effects of ferulic acid on gastrointe-stinal motility both in vitro and in vivo.

METHODS: Ferulic acid induced concentration-dependent stimulation of the basal tone of isolated guinea pig ileum (2-20 μmol/L) and isolated rat fundus (0.05-0.4 mmol/L).

RESULTS: Ferulic acid significantly accelerated the gastrointestinal transit and gastric emptying in rats in a dose-dependent manner (50-200 mg/kg, po). Cisplatin (2.5-20 mg/kg, ip) induced a dose-dependent delay in gastric emptying in rats. Pretreatment with ferulic acid dose-dependently, significantly reversed the cisplatin-induced delay in gastric emptying.

CONCLUSION: The endogenous prostaglandins (PGs) are involved in mediating the stimulant effects of ferulic acid. This effect of dietary ferulic acid may help improve other accompanying gastrointestinal symptoms such as abdominal discomfort and also may protect against emesis induced by cytotoxic drugs.

Keywords: Ferulic acid, Cisplatin, Gastric emptying, Rats