Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2

Table 1 Concentrations of PGE₂ , activities of MPO in colon tissue and mRNA in inflammatory response genes (mean ± SE)

	Tissue PGE2 (ng/g)	Protein MPO (knat/g)	TNF-α	mRNA IFN-γ	iNOS
Con 15	176.3 ± 29.2c	101 020 ± 17 170d	0.0795 ± 0.0096d	0.0284 ± 0.0150d	0.8304 ± 0.1180d
TNBS 8	78.5 ± 13.2a	249 382 ± 43 342b	0.8861 ± 0.0533b	1.0212 ± 0.0687b	6.5690 ± 0.9450b
CurL 12	190.2 ± 17.0c	121 691 ± 23 171ad	0.1967 ± 0.0365bd	0.0565 ± 0.0177ad	1.8638 ± 0.3347bd
CurH 13	215.5 ± 20.4ac	122 191 ± 21 171ad	0.1727 ± 0.0348bd	0.0518 ± 0.0057d	1.7250 ± 0.3026bd

^aP < 0.05, ^bP < 0.01 vs control; ^cP < 0.05, ^dP < 0.01 vs TNBS acid (Dunnett’s t test)