Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux

Table 1 Effects of various intraluminar treatments on the mean arterial pressure (MAP), heart rate (HR) and red blood cell velocity (RBCV, µm/s) and venular diameter (VD, µm) of the esophageal mucosa.

Group	Time	-30 min	0	30 min	60 min	90 min	120 min	180 min
	RBCV(M)	600	608	572	615	569	575	630
	25p; 75p	554; 661	548; 663	536; 662	526; 709	539; 673	524; 705	540; 705
	VD (M)	31	33	33	32	33	33	34
Saline	25p; 75p	27.3; 34.3	27.5;34.5	27.3;34.0	28.3; 34.8	28.3; 34.0	27.5; 34.0	31; 34
	MAP (M)	163	161	158	157	150	156	152
	25p; 75p	134.5;172	132; 175	130; 168	132;167	129;169	128; 168	129; 169
	HR (M)	172.5	171	169	167	177	180	181
	25p; 75p	126; 200	145; 183	151; 206	141.5; 198	142;195	141; 194	146; 188
	RBCV(M)	621	662	717	783 a	770 ac	777 ac	813 ac
	25p; 75p	573; 660	574; 693	610; 791	734; 821	686; 828	712; 836	728; 869
	VD (M)	33	33.5	41 ac	45.5 ac	43.0 ac	42.5 ac	43.5 ac
Bile	25p; 75p	33.0; 34.0	33; 35.0	39; 43.0	41.0; 48.0	41.0; 45.0	42.0; 44.0	42.0; 47
	MAP (M)	155	157	153	137	145	145	147
	25p; 75p	129; 185	131; 181	128; 184	127;185	126; 176	121; 181	127; 185
	HR (M)	167	171	161	161	181	177	192
	25p; 75p	160; 174	157; 191	149; 171	158; 170.5	141.5; 197	154; 197	153; 194
	RBCV(M)	600	651	789 c	809 ac	821 ac	784 ac	818 ac
	25p; 75p	554; 661	640; 703	698; 872	694; 888	715; 881	727; 806	724; 870
PC+ bile	VD (M)	31	35	37.0 ce	37.5 ce	39.0 ce	38.0 ce	38.0 ce
	25p; 75p	27.3; 34.3	32; 39.0	33.5; 40	35.5; 41.5	34.0; 41.0	33.0; 42.5	34.5; 42
	MAP (M)	163	147.5	161.5	152.5	150	162.5	160
	25p; 75p	134.5;172	130; 154	133; 170	131; 167.5	129; 168.5	132; 174	133; 173
	HR (M)	172.5	162	164	162.5	171	180	188
	25p; 75p	126; 200	145, 167	143; 180	148, 188	142; 199	158; 186	183; 198
	RBCV(M)	625	632	791 c	762 a	821 ac	793 c	872 ac
	25p; 75p	556; 696	614; 671	649; 870	661; 893	761; 870	718; 845	857; 893
7-NI+ bile	VD (M)	31	32	34.0 e	34.0 e	32.5 e	34.0 e	33.5 e
	25p; 75p	30.0; 31.0	29; 33.0	33; 36	34.0; 34.0	31.0; 36.0	32.0; 34.0	32; 34.0
	MAP (M)	132.5	138	145	137.5	141.5	135.5	139.5
	25p; 75p	128; 144	133; 150	132; 150	130; 151	134; 149	130; 143	135; 145
	HR (M)	170	163	171	165	181	185	186
	25p; 75p	162; 180	159, 169	158; 182	152; 178	173; 191	176.5; 196	182; 189

M = median value, 25p and 75p = 25^th and 75^th percentiles, respectively. ^aP < 0.05 vs -30-min values, ^cP < 0.05 vs saline-treated group, ^eP < 0.05 vs bile-treated group.