Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models

Table 1 Scoring system assessing the degree of fibrosis

Degree of fibrosis	Score
No fibrosis	0
Slight fibrosis expanding to some portal areas and central veins	I
Marked fibrosis expansion, but without portal to portal bridging	II
Fibrosis expanding to most portal areas with occasional portal to portal bridging	III
Pseudolobules formed and partly replacing the normal architecture of the liver lobules	IV
Occasional pseudolobules formed (incomplete cirrhosis)	V
Congested with pseudolobules, and between pseudolobules wide hyperplastic collagen fiber existed (complete cirrhosis)	VI

Table 2 Results of image pattern analysis of expression of TIMP-1 mRNA

Group	n	TIMP-1 mRNA
Immune groupa	7	421.90 ± 19.00
CCL4 groupc	7	188.80 ± 62.80
Control group	10	52.75 ± 4.25

^aP < 0.05 compared with CCL₄ group, t = 9.398;

^cP < 0.05 compared with control group, t = 3.414.