Effect of somatostatin analogue octreotide injected into the third cerebral ventricle on pentagastrin-induced gastric acid secretion in rats

Table 1 Effect of sc injection of G-5 or TCV injection of saline on gastric acid secretion (n = 10, mean ± SE)

Index	sc G-5		TCV saline
	1st time	2nd time	before	after
TAO (μmoL/h)	23.93 ± 3.83	26.66 ± 5.15	18.24 ± 1.72	18.86 ± 1.38
Change rate of TAO (%)	8.08 ± 5.46		5.90 ± 5.47

Table 2 Effect of TCV-injected Oct on G-5 stimulated gastric acid secretion (mean ± SE)

Group	n	TCV injection	Change rate of TAO (%)	P
1	10	Saline 2.5 μL	5.90 ± 5.47
2	12	Oct 0.025 μg/2.5μL	1.56 ± 6.63	> 0.05
3	12	Oct 0.05 μg/2.5μL	20.21 ± 6.49a	< 0.01
4	12	Oct 0.1 μg/2.5μL	37.82 ± 3.97	< 0.001

^aP < 0.05 vs group 2 or group 4.