Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity

Table 1 Distribution and frequency of LOH at 9 microsatellite loci in primary gastric carcinomas

Microsatelliteloci	Location onchromosome	LOH cases	Heterozygouscases	Positive rateof LOH (%)
D7S515	7q22.1	6	53	11.3
D7S486	7q31.1	12	50	24
D7S530	7q32.1	4	50	8
D7S640	7q33	3	63	4.8
D7S684	7q34	4	58	6.9
D7S661	7q35	3	27	11.1
D7S636	7q36.1	3	60	5
D7S798	7q36.2	5	26	19.2
D7S2465	7q36.3	5	52	9.6

Table 2 Correlation between frequencies and clinicopathology of LOH in primary gastric carcinomas

Clinicopathological variables		LOH frequency of chromosome 7(%)		χ2	P value	LOH frequency ofD7S486 (%)		χ2	P value
Gender	Male	17/52	(32.7)	0.22	0.636	7/35	(20)	1	0.317
	Female	7/18	(38.9)			5/15	(33.3)
Age (yr)	>53	14/37	(37.8)	0.43	0.51	7/26	(26.9)	0.25	0.618
	≤53	10/33	(30.3)			5/24	(20.8)
Clinical stage	I-II	3/20	(15)	6.16	0.046	1/13	(7.7)	2.63	0.268
	III	8/24	(33.3)			5/18	(27.8)
	IV	13/26	(50)			6/19	(31.6)
T stage	T1-2	3/13	(23.1)	0.88	0.349	1/8	(12.5)	0.68	0.411
	T3-4	21/57	(36.8)			11/42	(26.2)
Lymph node metastasis	No	4/19	(21.1)	2	0.158	0/13	(0)		0.015
	Yes	20/51	(39.2)			12/37	(32.4)
Distance metastasis	No	20/60	(33.3)	0.17	0.683	9/42	(21.4)		0.379
	Yes	4/10	(40)			3/8	(37.5)
Histopathological type	Tubular adenocarcinoma	5/15	(33.3)	2.79	0.425	2/9	(22.2)	0.12	0.989
	Poorly- differentiated carcinoma	9/25	(36)			6/22	(27.3)
	Signet-cell adenocarcinoma	6/19	(31.6)			3/12	(25)
	Undifferentiated adenocarcinoma	4/6	(66.7)			1/4	(25)