Effect of Chinese medicine Qinggan Huoxuefang on inducing HSC apoptosis in alcoholic liver fibrosis rats

Table 1 Impact of QGHXF on ALT, AST, ALP, and -GT in AF rats (mean±SD)

Group	n	ALT(nkat/L)	AST(nkat/L)	ALP(nkat/L)	GGT(nkat/L)
Norma	12	464  ±  90 b	1156  ± 2 50b	1065  ±  315b	360  ±  98b
CCl4	12	674  ±  172	1678  ±  293a	1695  ±  406a	748  ±  242a
Model	10	926  ±  154	3344  ±  330	2806  ±  639	1376  ±  215
Low dose	11	747  ±  113	2552  ±  388b	1748  ±  462a	982  ±  236a
Moderate dose	10	718  ±  156	2215  ±  650b	1632  ±  502a	869  ±  303a
High dose	10	615  ±  190bc	1972  ±  366bc	1570 ±  497a	770  ±  240b
XCH	10	867	2777 ± 608a	2413  ±  609a	768  ±  292b

^aP  <  0.05,

^bP  <  0.01 vs model group;

^cP  <  0.05 vs XCH.

Table 2 Effect of QGHXF on proliferation and cell cycle of HSC (n=6; mean±SD)

Group	Apoptotic rate (%)	Cell cycle
		G0/G1	S	G2/M	PI value (%)
Normal	4.47  ±  0.8	79.30  ±  1.03	1.69  ±  0.73	19.02  ±  1.67	20.71  ±  1.03
Low dose	10.07  ±  1.14a	37.47 ±  0.68b	1.46  ±  0.46a	61.07  ±  0.33b	62.53  ±  0.68b
Moderate dose	13.79  ± 2.26a	68.31  ±  0.92a	2.11  ±  0.46a	29.58  ± 1.38	31.69  ±  0.92a
High dose	22.4  ±  3.13b	71.25  ±  1.05b	2.70  ±  0.46	26.06  ±  1.47b	28.75  ±  1.05b
Model	6.58  ±  1.04	64.55  ±  1.53	3.69  ±  0.66	31.76  ±  0.87	35.45  ±  1.53

Proliferative index = 100 %×(S+G₂/M)/( G₀/G₁+S+G₂/M).

^aP <  0.05,

^bP <  0.01 vs model group.