Novel susceptibility genes in inflammatory bowel disease

Table 1 Number of patients studied and Toll-like receptor 4 Asp299Gly allele frequency (as a percentage of each group) in healthy controls, ulcerative colitis and Crohn’s disease patients

	Healthy controls (%)	Ulcerative colitis (%)	Crohn’s disease (%)	P value for controls versus Crohn’s disease(NS: not significant)
Franchimont et al, Belgium (28)	139 (5.0)	163 (10.0)	334 (11.0)	0.007
Arnott et al, Scotland (32)	189 (8.8)	246 (6.8)	234 (10.3)	NS
Torok et al, Germany (30)	145 (4.0)	98 (9.0)	102 (7.0)	NS
Gazouli et al, Greece (29)	100 (3)	85 (3.5)	120 (7.9)	0.026
Brand et al, Germany ( 31)	199 (7.5)		204 (14.2)	0.038
Oostenbrug et al, Netherlands (33)	296 (4.6)	179 (5.9)	393 (6.7)	NS

These data from 6 European case control studies looking at the allelic frequencies of the Asp299Gly polymorphism of the TLR4 gene illustrate the contrasting results from these studies, and furthermore suggest a degree of genetic heterogeneity between the different populations.