Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma

Table 1 Pathological characteristics of gastric adenocarcinoma and immunohistochemical COX-2 staining.

Pathological characteristics	n	Expression of COX-2				Positive rate (%)	P
		-	+	++	+++
Gastric carcinomas	36	8	12	10	6	77.8	<0.01b
Para-cancerous tissues	36	19	10	7	0	47.2
Location of tumor
Cardiac carcinoma	16	1	4	8	3	93.8	<0.01b
Non-cardiac carcinoma	20	7	8	2	3	65
Histological type
Intestinal carcinoma	17	3	5	5	4	82.3
Diffuse carcinoma	19	5	7	4	3	74.1
Metastatic lymph node
Positive	22	1	10	5	6	95.5	<0.005b
Negative	14	7	2	5	0	50.0

^bP<0.01 vs the expression of COX-2 was significant between gastric carcinoma and para-cancerous tissues, location of tumor, and metastatic lymph node.

Table 2 Expression of bcl-2 in gastric cancer and para-cancerous tissues.

Type of tissue	n	Expression of bcl-2				Positive rate (%)	P
		-	+	++	+++
Gastric cancer tissue	36	7	9	12	8	80.56	<0.025a
Para-cancerous tissues	36	15	14	4	3	58.33

^aP<0.05 vs the expression of bcl-2 was significant between gastric carcinoma and para-cancerous tissues.