Fibroblast growth factor-4 and hepatocyte growth factor induce differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocytes

Table 1 Concentrations of AFP, albumin and urea in the medium at different time points (mean±SE)

Group	4 d	8 d	12 d	16 d	20 d	24 d	28 d
AFP (μg/L)
Differentiation	15.92±0.76	15.72±1.06	18.20±1.16a	20.57±1.98a	38.53±6.07a	39.47±4.06b	54.28±3.11b
Control	15.77±0.72	14.30±0.69	14.67±1.10	13.72±0.40	16.57±1.03	14.13±1.11	15.67±0.93
Albumin (μg/mL)
Differentiation	–	–	0.63±0.07	1.02±0.15b	1.45±0.21b	3.08±0.35b	3.63±0.30b
Control	–	–	0.40±0.12	0.20±0.06	0.15±0.06	0.22±0.07	0.25±0.10
Urea (μmol/L)
Differentiation	–	–	–	–	4.72±1.03b	7.27±0.89b	10.28±1.06b
Control	–	–	–	–	0.47±0.30	0.87±0.43	0.55±0.26

^aP<0.05 vs control,

^bP<0.01 vs control, – stands for what could not detected. n = 6