DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor

Table 1 Statistical summary of Ku70/80 DNA binding activity and Ku70 protein expression in pathological samples and matched normal tissues (mean±SD)

Colon	Ku70/80 DNA binding activity			Ku70 protein expression
Tissue	Normal	Tumor	P	Normal	Tumor	P
Adenomas	2.66±2.32	5.01±3.15	<0.01	0.88±0.59	1.28±0.45	<0.01
Carcinomas	2.99±2.84	5.35±2.75	<0.001	1.09±0.80	1.77±0.83	<0.01

Table 2 Ku70 and Ku86 nuclear immunostaining in adenomas and matched normal tissues

Adenomas	Ku70		Ku86
	Normal	Tumor	Normal	Tumor
A1	61	93	40	81
A2	65	81	33	70
A3	60	83	31	63
A4	61	82	35	71
A5	65	79	32	75
A6	58	68	39	62
A7	64	74	26	62
A16	51	75	25	71
A17	79	92	24	63
A19	61	87	29	62
Carcinomas
K1	66	95	27	78
K2	48	76	37	62
K3	66	84	26	71
K4	47	86	40	86
K5	72	85	34	70
K6	76	86	26	61
K7	72	88	28	76
K8	51	92	17	79
K9	62	96	44	65
K10	65	90	51	71
K11	56	94	51	66
K12	52	82	34	73
K13	65	85	25	66
K14	52	92	18	64
K15	65	73	28	65

Table 3 Statistical summary of Ku70 and Ku86 nuclear immu-nostaining in pathological samples and matched normal tissues (mean±SD)

Colontissue	Ku70			Ku86
	Normal	Tumor	P	Normal	Tumor	P
Adenomas	63.39±7.72	80.22±7.52	0.000	30.48±5.43	67.57±7.64	0.000
Carcinomas	61.42±9.66	87.34±6.97	0.000	32.86±11.29	70.36±7.55	0.000
Healthy	74.20±6.38	-	-	32.00±5.10	-	-