Effect of cytokine gene polymorphism on histological activity index, viral load and response to treatment in patients with chronic hepatitis C genotype 3

Table 1 Statistical significance of effects of cytokine gene polymorphisms on different parameters

Cytokine gene polymorphism	ALT (upper limit normal)	HCV RNA level	Grade of inflammation	Stage of fibrosis	Steatosis	Lymph follicles	End of treatment response	Sustained response
			(0-18)	(0-6)	(0-3)
IL 10 -1082	0.636	0.241	0.029	0.079	0.267	0.848	0.078	0.331
(GA, AA, GG)
IL 10 -819	0.794	0.781	0.412	0.020	0.57	0.295	0.063	0.331
(AC, CC, AA)
IL 10 -592	0.582	0.198	0.243	0.281	0.551	0.626	0.416	0.283
(CA, CC)
IFNγ -874	0.389	0.848	0.919	0.921	0.955	0.382	0.21	0.933
(AA, TT, TA)
TNFα -308	0.952	0.436	0.777	0.307	0.32	0.85	0.674	0.451
(AG, GG)
TGFβ -10	0.734	0.72	0.386	0.959	0.232	0.643	0.026	0.206
(CC, TC, TT)
IL 1 (C/U)	0.144	0.591	0.964	0.826	0.326	0.836	1.00	1.00

P values were calculated by ANOVA and Pearson’ s χ² test. Statistically significant values. IL: interleukin; IFNγ: interferon gamma; TNFα: tumor necrosis factor alpha; TGFβ: transforming growth factor beta.