Expression and significance of CD44s, CD44v6, and nm23 mRNA in human cancer

Table 1 Relationship between expression of CD44s, CD44v6, nm23 mRNA and pathologic feature of human colorectal adenocarcinoma

Pathologic	n	CD44s		CD44v6		nm23 mRNA
feature		Positive (%)	P	Positive (%)	P	Positive (%)	P
Grade			>0.05		<0.05a		>0.05
II	16	7(43.7)		11(68.7)		8(50.0)
I	24	10(41.6)		11(45.8)		10(41.6)
Invasion			<0.01b		<0.01b		<0.05C
+	17	11(64.7)		12(70.5)		5(29.4)
–	23	6(26)		10(43.4)		13(56.5)
Metastasis			<0.0d		<0.05e		<0.05e
+	14	9(64.2)		10(71.4)		4(28.5)
–	26	8(30.7)		12(46.1)		4(53.8)
Age/yr			>0.05		>0.05		>0.05
>60	19	8(42.1)		10(52.6)		8(42.1)
<60	21	9(42.8)		12(57.1)		10(47.6)
Sex			>0.05		>0.05		>0.05
M	26	10(38.4)		14(53.8)		12(46.1)
F		7(50)		8(57.1)		6(42.8)
Normal		4(18.1)		0(0)		9(40.9)

^aP<0.05 vs poorly differentiated colorectal adenocarcinoma; ^cP<0.05,

^bP<0.01 vs without invasion;

^eP<0.05,

^dP<0.01 vs without metastasis.

Table 2 Relationship between expression of CD44s, CD44v6, nm23 mRNA, and pathologic feature of human gastric adenocarcinoma

Pathologic	n	CD44s			CD44v6			nm23 mRNA
feature		Positive	%	P	Positive	%	P	Positive	%	P
Grade				>0.05			b<0.01			>0.05
II	20	8	40.0		10	50.0		9	45.0
III	20	10	50.0		15	75.0		10	50.0
Invasion				>0.05			d<0.01			>0.05
+	23	11	47.8		18	78.2		11	47.8
–	17	7	41.1		7	41.0		8	47.1
Metastasis				>0.05			f<0.01			f<0.01
+	15	6	40.0		12	80.0		4	26.7
–	25	12	48.0		13	52.0		15	60.0
Age/year				>0.05			>0.05			>0.05
>60	21	10	47.2		13	61.9		9	42.9
<60	19	8	42.1		12	63.1		10	52.6
Normal	22	3	13.6		0	0		9	43.0

^bP <0.01 vs well-differentiated gastric adenocarcinoma;

^dP <0.01 vs without invasion;

^fP <0.01 vs without metastasis.

Table 3 Relationship between the expression of CD44s and CD44v6 and pathologic feature of human intraductal breast carcinoma

Pathologic	n	CD44s			CD44v6
features		Positive	%	P	Positive	%	P
Grade				>0.05			<0.05a
II	86	38	44.2		40	46.5
III	34	17	50		24	70.1
Invasion				<0.01b			<0.01b
+	58	35	60.3		44	75.9
–	62	20	32.3		20	32.3
Metastasis				<0.01d			<0.01d
+	30	21	70		23	76.7
–	90	34	37.8		41	45.6
Age(yr)				>0.05			>0.05
>50	66	31	47.1		34	51.5
<50	54	24	44.4		30	55.6
Normal	20	0	0		0	0

^aP<0.05 vs well-differentiated intraductal breast carcinoma;

^bP<0.01 vs without invasion;

^dP<0.01 vs without metastasis.

Table 4 Relationship between expression of nm23 mRNA and pathologic feature of lung cancer

Pathologic	n	nm23 mRNA
feature		Positive	%	P
Grade				<0.01b
I	19	3	15.8
II	13	7	53.8
III	20	17	85
Metastasis				<0.01d
+	24	6	25
–	48	34	70.8
Sex				>0.05
M	51	28	54.9
F	21	12	57.1
Age(yr)				>0.05
>55	42	22	52.3
<55	30	18	60
Normal	23	19	82.6

^bP<0.01 vs moderately and well-differentiated lung cancer;

^dP<0.01 vs without metastasis.