Inhibitory effects of N-(4-hydrophenyl) retinamide on liver cancer and malignant melanoma cells

Table 1 Apoptotic effects induced by 4-HPR (mean±SD, n = 3)

	Control	4-HPR	ATRA	As2O3
7721-k3 cells	4.27 ± 0.06	8.53 ± 0.12	5.05 ± 0.03	24.27 ± 0.39
P		> 0.05	> 0.05	< 0.05
B16 melanoma cells	1.65 ± 0.16	37.11 ± 0.94	2.38 ± 0.38	ND
P		< 0.05	> 0.05

ND, not determined.

Table 2 4-HPR-induced apoptosis in CST overexpressed B16 melanoma cells (mean±SD, n = 3)

	Parent cells	Mock cells	CST1	CST3
Control	1.64±1.16	1.37±0.30	2.61±0.61	1.37±0.374
4-HPR	37.11±0.95	38.030±1.002	32.65±1.98a	33.59±0.91a

^aP<0.05 vs mock cells.