Copyright
©The Author(s) 2005.
World J Gastroenterol. Sep 28, 2005; 11(36): 5721-5724
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5721
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5721
Table 1 Distribution of HLA-DRB1 alleles in CHB patients and wealthy people
| HLA-DRB1 | Patients with CHB | Wealthy people | OR (95%CI) | P | |||
| N1 | Allele frequencyn = 144 | N2 | Allele frequencyn = 400 | ||||
| DRB1*01 | 2 | 1.39 | 3 | 0.75 | 1.864 | (0.308 - 11.269) | 0.612 |
| DRB1*04 | 14 | 9.72 | 53 | 13.25 | 0.705 | (0.378 - 1.314) | 0.303 |
| DRB1*06 | 3 | 2.08 | 0 | 3.837 | (3.329 - 4.422) | 0.018 | |
| DRB1*07 | 4 | 2.78 | 31 | 7.75 | 0.34 | (0.118 - 0.981) | 0.046 |
| DRB1*08 | 16 | 11.11 | 22 | 5.5 | 2.148 | (1.094 - 4.216) | 0.034 |
| DRB1*09 | 34 | 23.61 | 75 | 18.75 | 1.339 | (0.846 - 2.120) | 0.225 |
| DRB1*10 | 4 | 2.78 | 4 | 1 | 2.829 | (0.698 - 11.462) | 0.217 |
| DRB1*11 | 11 | 7.64 | 29 | 7.25 | 1.058 | (0.514 - 2.178) | 0.854 |
| DRB1*12 | 20 | 13.89 | 66 | 16.5 | 0.816 | (0.475 - 1.402) | 0.507 |
| DRB1*13 | 2 | 1.39 | 15 | 3.75 | 0.362 | (0.082 - 1.601) | 0.262 |
| DRB1*14 | 9 | 6.25 | 25 | 6.25 | 1 | (0.455 - 2.197) | 1 |
| DRB1*15 | 9 | 6.25 | 39 | 9.75 | 0.617 | (0.291 - 1.308) | 0.234 |
| DRB1*16 | 10 | 6.94 | 12 | 3 | 2.413 | (1.019 - 5.713) | 0.049 |
| DRB1*17 | 6 | 4.17 | 26 | 6.5 | 0.625 | (0.252 - 1.552) | 0.409 |
Table 2 Distribution of HLA class II alleles in IFN responders and non-responders
| HLA | Responder | Non-responder | OR (95%CI) | P | ||
| N1 | Allele frequencyn = 22 | N2 | Allele frequencyn = 48 | |||
| DRB1*01 | 0 | 0 | 1 | 2.08 | 1.468 (1.249–1.725) | 1.000 |
| DRB1*04 | 2 | 9.09 | 7 | 14.58 | 0.586 (0.111–3.080) | 0.709 |
| DRB1*06 | 0 | 0 | 1 | 2.08 | 1.468 (1.249–1.725) | 1.000 |
| DRB1*07 | 1 | 4.55 | 2 | 4.17 | 1.095 (0.094–12.760) | 1.000 |
| DRB1*08 | 2 | 9.09 | 3 | 6.25 | 1.500 (0.232–9.685) | 0.646 |
| DRB1*09 | 3 | 13.64 | 11 | 22.92 | 0.531 (0.132–2.135) | 0.524 |
| DRB1*10 | 1 | 4.55 | 2 | 4.17 | 1.095 (0.094–12.760) | 1.000 |
| DRB1*11 | 1 | 4.55 | 5 | 10.42 | 0.410 (0.045–3.731) | 0.657 |
| DRB1*12 | 2 | 9.09 | 9 | 18.75 | 0.433 (0.085–2.199) | 0.483 |
| DRB1*14 | 4 | 18.18 | 1 | 2.08 | 10.444 (1.092–99.855) | 0.031 |
| DRB1*15 | 2 | 9.09 | 1 | 2.08 | 4.700 (0.403–54.835) | 0.231 |
| DRB1*16 | 3 | 13.64 | 2 | 4.17 | 3.632 (0.561–23.500) | 0.316 |
| DRB1*17 | 1 | 4.55 | 3 | 6.25 | 0.714 (0.070–7.281) | 1.000 |
| DQB1*02 | 2 | 9.09 | 3 | 6.25 | 1.500 (0.232–9.685) | 0.646 |
| DQB1*04 | 1 | 4.55 | 1 | 2.08 | 2.238 (0.134–37.516) | 0.533 |
| DQB1*05 | 7 | 31.82 | 8 | 16.67 | 2.333 (0.720–7.557) | 0.210 |
| DQB1*06 | 4 | 18.18 | 2 | 4.17 | 5.111 (0.860–30.310) | 0.073 |
| DQB1*07 | 2 | 9.09 | 18 | 37.5 | 0.167 (0.035–0.796) | 0.021 |
| DQB1*08 | 1 | 4.55 | 5 | 10.42 | 0.410 (0.045–3.731) | 0.657 |
| DQB1*09 | 5 | 22.73 | 11 | 22.92 | 0.989 (0.297–3.295) | 1.000 |
- Citation: Han YN, Yang JL, Zheng SG, Tang Q, Zhu W. Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients. World J Gastroenterol 2005; 11(36): 5721-5724
- URL: https://www.wjgnet.com/1007-9327/full/v11/i36/5721.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i36.5721