Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case report

Table 1 Comparison of CT density and light and electron micro-scopic findings between biopsy and autopsy specimens of the liver

	Biopsy	Autopsy
CT density (HU)	111.8	97.2
Light microscopic findings
Nodular formation	Micronodular	Micronodular
Fibrosis	Dense	Dense
Steatosis	Macro/microvesicular	Microvesicular
Infiltration of inflammatory cells	Moderate	Moderate
Electron microscopic findings
Number of lysosomes with	992/2 726 (36.4%)	862/2 578 (33.4%)
lamellar inclusion/total
number of lysosomes (%)1

¹Counts were performed of 10 fields (×18 000) of five blocks for each material.

Table 2 Summary of published cases of cirrhosis after long-term administration of daily low doses of AD

No	Reference	Age (yr)	Duration (mo)	Cumulative dose (g)	Outcome
1	Present case	85	84	528	Dead
2	12	76	48	Not described	Dead
3	13	68	13.5	165	Dead
4	14	77	12	202	Dead
5	18	79	33	200	Dead
6	19	83	35	213	Non-fatal