Brief Reports
Copyright ©The Author(s) 2005.
World J Gastroenterol. Sep 14, 2005; 11(34): 5347-5350
Published online Sep 14, 2005. doi: 10.3748/wjg.v11.i34.5347
Table 1 Clinical details of the patients
PBCHCV+Control group
Number of patients354933
Age (mean±SD), yr52.5 ± 1052.9 ± 5.851.8 ± 2.22
Age at menopause (mean±SD), yr48.3 ± 4.548.5 ± 4.947 ± 7.46
BMI (mean±SD)22.8 ± 3.2a23.4 ± 4.2a25.9 ± 4.29
Table 2 Bone metabolism in PBC, in HCV+ patients and in healthy controls
PBCHCV+Controls
BMD (lumbar spine)0.810 ± 0.1300.860 ± 0.1400.972 ± 0.128
t-score≤–2.5 SD–1.55 ± 0.99a–0.39 ± 2.65–0.29 ± 0.98
z-score–0.94 ± 1.10c–0.52 ± 1.23–0.82 ± 1.02
25-OHD (nmol/L)103.48 ± 58.85e98.38 ± 44.65g49.66 ± 19.72
BGP (mg/L)8.80 ± 8.76.43 ± 11.149.56 ± 2.92
Intact (1–84) PTH (ng/L)39.8 ± 26.335 ± 29.7833.60 ± 11.77
Ca corr albumin (mg/dL)2.27 ± 0.262.32 ± 0.132.31 ± 0.14
Table 3 Univariate analysis
VariablenOsteoporosis
P
n%
Menopausal status
Yes4610(21.7)
No382(5.2)0.032
Disease
HCV497(14.3)
PBC355(14.3)1
Normal 25-OH vit D
Yes6710(14.9)
No172(11.8)0.739
Normal BGP
Yes184(22.2)
No668(12.1)0.278
Serum PTH
Normal485(10.4)
High367(19.4)0.242
BMI >23
Yes564(7.1)
No288(25.8)0.008
Table 4 Multivariate analysis
VariableAdjusted OR95.0%CI
P
LowUpper
Disease (HCV vs PBC)0.4290.0862.1490.304
BGP1.7850.3239.8660.507
25-OH vit D0.6740.0984.6090.687
PTH2.0500.4948.5010.323
Menopausal status23.1021.524350.1860.024
BMI < 235.7031.22826.4880.026
Age (yr)1.1511.0041.3200.044