Different profile of cytokine synthesis according to the severity of acute pancreatitis

Table 1 IL-6, IL-8, TNF-α and IL-10 levels in groups I-III

		IL-6 (pg/mL)	IL-8 (pg/mL)	TNF-α (pg/mL)	IL-10 (pg/mL)
SAP	Basal	105.6 (52.0-210)a	46.8 (26.2-95)b	15.8 (7.1-21.7)b	17.7 (7.5-29.4)c
	24 h	208.0 (140-476)e	872.0 (316-3 280)e	58.7 (52-132)e	12.5 (8.4-34.6)
	24 h+PHA	925.0 (303-1 219)g	2 715.0 (760-8 599)g	473.0 (308-518)g	7.2 (2.2-47.3)
MAP	Basal	15 (5.4-33.2)	18.5 (1.2-33.6)	7.9 (4.1-17.7)	7.3 (4.1--1.6)
	24 h	133.0 (53.6-856)e	1 611.0 (484-4 336)e	62.4 (45.5-100.5)e	20.8 (6.5-44.1)e
	24 h+PHA	2057.0 (605-4 189)g	8 045.0 (3 377-28 209)g	540.5 (422-824.7)g	51.9 (32.1-131.3)g
Controls Basal		3.2 (0.9-6.7)	35.6 (17.9-93.7)	4.3 (2.2-6.1)	9.4 (6-14.4)
	24 h	7.1 (4.9-9.6)	46.9 (32.2-94.5)	7.1 (4.1-10.1)	21.3 (18.3-34.5)
	24 h+PHA	610.0 (404.7-1 026)g	1 396.0 (962-3 065.2)g	792.0 (573.2-1 064.7)g	53 (43.4-80.1)g

Data are shown as median (25^th-75^th percentiles). SAP: severe acute pancreatitis; MAP: mild acute pancreatitis; controls: healthy controls; basal: samples obtained within 72 h from the onset of symptoms; 24 h: supernatant of culture after 24 h without stimulation; 24 h+PHA: supernatant of culture after 24 h with addition of PHA to the culture media; IL-6, IL-8, and IL-10: interleukins 6, 8 and 10 respectively; TNF-α: tumor necrosis factor-α.

^aP < 0.05 vs the corresponding values in groups II and III;

^bP < 0.01 vs the corresponding value in group II;

^cP < 0.05 vs the corresponding value in group II;

^eP < 0.05 vs basal levels within each group;

^gP < 0.05 vs 24 h levels within each group.