Implications of anti-parietal cell antibodies and anti-Helicobacter pylori antibodies in histological gastritis and patient outcome

Table 1 Baseline characteristics of all patients

	1HC(n = 42, %)	2DU(n = 52, %)	3GU(n = 14, %)	4GC(n = 44, %)
Age (mean±SD) (yr)	48.2 ± 13.3	51.2 ± 14.3	71.6 ± 10.7a	68.8 ± 13.7a
Sex: male	19 (45)	34 (65)	10 (71)	37 (84)a
Blood type
A	15 (36)	13 (25)	6 (42)	12 (27)
B	11 (26)	16 (31)	2 (14)	11 (25)
O	13 (31)	21 (40)	5 (36)	17 (39)
AB	3 (7)	2 (4)	1 (7)	4 (9)
Smoking	12 (29)	19 (37)	10(71)a	15 (34)
Daily alcohol use	4 (10)	5 (10)	4 (29)	6 (14)
Daily coffee use	6 (14)	3 (6)	1 (7)	2 (5)
Daily tea use	11 (26)	17 (33)	5 (36)	8 (18)

¹HC: healthy control; ²DU: duodenal ulcer; ³GU: gastric ulcer; ⁴GC: gastric cancer.

^aP<0.05 vs healthy control group.

Table 2 Prevalence rate of H pylori infection and anti-parietal cell antibodies among various groups of patients

	1HC	2DU	3GU	4GC
	(n = 42, %)	(n = 52, %)	(n = 14, %)	(n = 44, %)
H pylori infection	10 (24)	39 (75)a	8 (57)a	23 (53)a
5PCA	15 (36)	23 (44)	11 (79)a	31 (70)a

¹HC: healthy control; ²DU: duodenal ulcer; ³GU: gastric ulcer; ⁴GC: gastric cancer;

⁵APCA: anti-parietal cell antibodies.

^aP < 0.05 vs healthy control group.

Table 3 Host and bacterial factors related to the presence of anti-parietal cell antibodies (APCA) in serum

	Anti-parietal cell antibodies			P
	Positive(n = 80, %)	Negative(n = 72, %)	Absolute difference(95%CI)
Age≥60 (yr)	48 (60)a	17 (24)	0.36 (0.22-0.51)	0
Sex (male)	58 (73)	42 (58)	0.14 (-0.01-0.29)	0.07
Blood type
A	23 (29)	23 (32)	-0.03 (-0.18-0.12)	0.67
B	21 (26)	19 (26)	-0.00 (-0.14-0.14)	0.99
O	32 (40)	26 (36)	0.04 (-0.12-0.20)	0.63
AB	4 (5)	4 (6)	-0.01 (-0.08-0.07)	0.88
Smoking	34 (43)	22 (31)	0.12 (-0.03-0.27)	0.13
Daily alcohol use	13 (16)	6 (8)	0.08 (-0.03-0.19)	0.14
Daily coffee use	3 (4)	9 (13)	-0.09 (-0.17-0.00)	0.05
Daily tea use	24 (30)	17 (24)	0.06 (-0.08-0.21)	0.38

^aP<0.05 vs APCA (-) group.

Table 4 Host and bacterial factors related to the presence of anti-H pylori antibodies (AHPA) in serum

	Anti-H pylori antibodies			P
	Positive(n = 82, %)	Negative(n = 70, %)	Absolute difference(95%CI)
Age≥60 (yr)	30 (37)	35 (50)	-0.13 (-0.29-0.02)	0.1
Sex (male)	59 (72)	41 (58)	0.13 (-0.02-0.29)	0.08
Blood type
A	25 (30)	21 (30)	0.00 (-0.14-0.15)	0.95
B	22 (27)	18 (26)	0.01 (-0.13-0.15)	0.88
O	31 (38)	27 (39)	-0.01 (-0.16-0.15)	0.92
AB	4 (5)	4 (6)	-0.01 (-0.08-0.06)	0.82
Smoking	31 (38)	25 (36)	0.02 (-0.14-0.18)	0.79
Daily alcohol use	13 (16)	6 (9)	0.07 (-0.03-0.18)	0.18
Daily coffee use	9 (11)	3 (4)	0.07 (-0.02-0.15)	0.13
Daily tea use	24 (29	17 (24)	0.05 (-0.09-0.19)	0.49

Table 5 Multivariant logistic regression analysis of factors influenc-ing severe atrophy in antrum

Variables	Exp(B)	SE	Wald	Sig
Age (yr)	1.0003	0.0165	0.0004	0.98
Sex	0.8724	0.5639	0.0586	0.81
Blood_A	0.6916	0.5468	0.4547	0.50
Blood_B	0.5688	0.5129	1.2106	0.27
Blood_O	0.6418	0.5042	0.7736	0.38
Blood_AB	1.1187	0.3705	0.0917	0.76
Smoking	1.0790	0.5127	0.022	0.88
Alcohol	2.0850	0.6279	1.3694	0.24
Coffee	1.3520	0.8278	0.1328	0.72
Tea	0.9952	0.488	0.0001	0.99
1AHPA	2.8104	0.4768	4.6965	0.03
2APCA	1.5004	0.4863	0.6961	0.40

¹AHPA: anti-H pylori antibodies;

²APCA: anti-parietal cell antibodies.

Table 6 Multivariant logistic regression analysis of factors influenc-ing severe atrophy in corpus

Variables	Exp(B)	SE	Wald	Sig
Age (yr)	1.0272	0.0301	0.7907	0.37
Sex	3.1120	1.2611	0.8104	0.37
Blood_A	0.5556	0.8903	0.4358	0.51
Blood_B	0.5490	0.7726	0.6023	0.44
Blood_O	0.3659	0.8854	1.289	0.26
Blood_AB	0.6659	0.3478	1.3675	0.24
Smoking	1.0528	0.8430	0.0037	0.95
Alcohol	3.3423	0.8884	1.8446	0.17
Coffee	0.0003	1.4524	2.3234	0.13
Tea	3.8250	0.8091	2.7494	0.10
1AHPA	1.8250	0.8418	0.5106	0.47
2APCA	25.1000	1.3096	6.0565	0.01

¹AHPA: anti-H pylori antibodies;

²APCA: anti-parietal cell antibodies.