Association between TRAIL expression on peripheral blood lymphocytes and liver damage in chronic hepatitis B

Table 1 Demographic data, HBV marker and histological findings of the liver in the study population

Characteristics	Normal control	Chronic HBV infection
		CH1	CH2-3	CSH	LC
Number	17	13	14	16	15
Male:female	12:5	9:4	10:4	11:5	11:4
Median age (range)	33.5 (26-50)	34 (24-58)	36 (23-64)	33 (24-56)	44 (21-68)
ALT (U/L)	33 ± 12	57.8 ± 73.6	190.3 ± 207.8	238.3 ± 381.2	85.5 ± 60.4
TBIL (mmol/L)	15 ± 5.2	22.4 ± 20.1	70.0 ± 46.7	405.8 ± 132.9	64.4 ± 47.4
Alb (g/L)		40.78 ± 5.3	35.4 ± 6.8	31.8 ± 3.6	34.9 ± 4.5
PT (s)		13.7 ± 3.4	17.4 ± 5.2	32.1 ± 10.9	21.8 ± 6.4
HBV DNA (positive cases)	0	9	10	4	7
Liver histological findings
Not done (n)	17		8	11	9
G0-1 (n)		11
G2-3 (n)		2	6
G4 (n)				5	6

Table 2 Changes of serum sTRAIL and modulations of membrane-bound TRAIL expression on peripheral T lymphocytes in chronic hepatitis

Group	n	CD4+ T lymphocyte	CD8+ T lymphocyte	sTRAIL
		TRAIL expression (%)	TRAIL expression (%)	(pg/mL)
CH1	13	2.82 ± 1.00b	5.10 ± 2.01b	1001.93 ± 474.23
CH2–3	14	4.64 ± 2.08b	6.56 ± 3.56b	1358.38 ± 391.66b
CSH	16	5.33 ± 2.38b	8.31 ± 3.62b	969.56 ± 377.41
Cirrhosis	13	4.20 ± 1.92b	5.09 ± 2.50b
Normal	17	1.21 ± 0.57	3.04 ± 1.72	800.24 ± 322.9

^bP < 0.001 vs normal controls.

Table 3 Positive correlation between liver histological findings and membrane-bound TRAIL expression

Inflammation	n	CD4+ T lymphocyte	CD8+ T lymphocyte
grade		TRAIL expression (%)	TRAIL expression (%)
G0-1	11	2.51 ± 0.96	5.22 ± 2.25
G2-3	8	4.66 ± 2.30a	6.43 ± 3.00a
G4	11	4.74 ± 2.00a	7.92 ± 3.58a

^aP<0.05 vs G_0–1.