Role of Helicobacter pylori eradication in aspirin or non-steroidal anti-inflammatory drug users

Table 1 Recommendations[19,48] and evidence for the H pylori test-and-treat approach and/or the long-term therapy with a proton pump inhibitor (PPI) in users of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs)

	H pylori test-and-treat approach	Long-term PPI therapy
Naive aspirin users	Recommendation	No
Naive NSAIDs users	Recommendation-evidence[39,40]	No
Chronic aspirin users
With a recent ulcer complication	Recommendation1-evidence[46,47]	Recommendation-evidence[47]
At high risk for ulcer complication	Recommendation1	Recommendation
At low risk for ulcer complication	No	No
Chronic NSAIDs users
With a recent ulcer complication	Potential benefit12	Recommendation-evidence[46]
At high risk for ulcer complication	Potential benefit12	Recommendation
At low risk for ulcer complication	No	No

¹H pylori eradication therapy in chronic users of aspirin or NSAIDs with a recent ulcer complication or those at a high-risk should be administered after confirmation of ulcer healing.

²H pylori eradication therapy in chronic NSAIDs users with a recent ulcer complication or those at a high-risk may be given as a potentially beneficial intervention in addition to the long-term PPI therapy.